| 中文名称: | PD-168077 maleate 促销 | ||||
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| 英文名称: | PD-168077 maleate | ||||
| CAS No: | 630117-19-0 | 分子式: | C24H26N4O5 | 分子量: | 450.49 |
| CAS No: | 630117-19-0 | ||||
| 分子式: | C24H26N4O5 | ||||
| 分子量: | 450.49 | ||||
基本信息
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产品编号： |
P11012 |
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产品名称： |
PD-168077 maleate |
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CAS: |
630117-19-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
450.49 |
-20℃ |
1个月 |
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化学名： |
Benzamide,N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-,(2Z)-2-butenedioate (1:1);PD 168077 maleate |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.2198mL |
11.0990mL |
22.1981mL |
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5mM |
0.4440mL |
2.2198mL |
4.4396mL |
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10mM |
0.2220mL |
1.1099mL |
2.2198mL |
生物活性
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产品描述 |
一个选择性的多巴胺 D4 受体激动剂，其 Ki 值为 9nM。 |
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靶点 |
Ki:9nM (Dopamine D4 receptor) |
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体外研究 |
PD-168077 is one of the first agents to be identified as putative selective D4 agonists.It shows>100-fold selectivity over other members of the D2-like receptor family and over their D1-like counterparts;PD-168077 shows a 20-fold selectivity over α1,andα2, a 45-fold selectivity over 5-HT1A,and a 460-fold selectivity over 5-HT2A receptors;PD-168077 evidences intrinsic activity at the D4 receptor in terms of quinpirole-like inhibition of forskolin-stimulated cAMP accumulation or stimulation of [3H]thymidine uptake in CHO cells expressing the human D4 receptor.In the PD-168077-treated cell,p-CaMKII exhibits a significantly increased clustering at synaptic sites,as indicated by the enhanced colocalization with PSD-95. |
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体内研究 |
PD-168077 (0.2-25.0mg/kg) dose-dependently induces locomotion,which takes an unusual and characteristic”shuffling”form with uncoordinated movements together with yawning,and episodes of myoclonic jerking;grooming, and rearing are reduced. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
