基本信息
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产品编号： |
P10977 |
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产品名称： |
Phenylephrine |
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CAS: |
59-42-7 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
167.21 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
5.9805mL |
29.9025mL |
59.8050mL |
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5mM |
1.1961mL |
5.9805mL |
11.9610mL |
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10mM |
0.5981mL |
2.9903mL |
5.9805mL |
生物活性
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产品描述 |
是选择性的α1-肾上腺素受体激动剂，主要用作减充血剂。 |
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靶点 |
Adrenergic Receptor |
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体外研究 |
(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86,4.87 and 4.70 for α1D,α1B and α1A receptors respectively.Phenylephrine promotes cardiac fibroblast proliferation.Phenylephrine activates CaN and evokes NFAT3 nuclear translocation.It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine-induced cardiac fibroblast proliferation,and this pathway might be a possible therapeutic target in cardiac fibrosis. |
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体内研究 |
Perfusion of hearts with 100μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms.α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes.Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats: A total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables.Short-term (40 minutes) mechanical ventilation with high tidal volume is performed to induce lung injury,impair active Na+transport and lung liquid clearance in the rats.Unventilated rats serves as controls.To demonstrate the effect of phenylephrine on alveolar fluid clearance,phenylephrine at different concentrations (10,1,0.1,0.01,and 0.001μM) is injected into the alveolar space of the HVT ventilated rats. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
