Pregnenolone monosulfate - CAS:1247-64-9 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Pregnenolone monosulfate
英文名称:	Pregnenolone monosulfate
别名:	3β-Hydroxy-5-pregnen-20-one monosulfate
CAS No:	1247-64-9	分子式:	C₂₁H₃₂O₅S	分子量:	396.54
CAS No:	1247-64-9
分子式:	C₂₁H₃₂O₅S
分子量:	396.54

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P10875 Pregnenolone monosulfate ≥98% (psaitong)

相关产品

包装规格：

25mg in glass bottle

溶解性：

溶于DMSO（62.5 mg/mL 超声）溶液状态不稳定，建议现配现用。

产品描述：

基本信息

产品编号：	P10875
产品名称：	Pregnenolone monosulfate
CAS:	1247-64-9	储存条件	粉末	-20℃充氮保存	四年

分子式：	C21H32O5S		溶于液体	-80℃	6个月
分子量：	396.54			-20℃	1个月
化学名：	[(3S,8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.5218mL	12.6091mL	25.2181mL
5mM	0.5044mL	2.5218mL	5.0436mL
10mM	0.2522mL	1.2609mL	2.5218mL

生物活性

产品描述	一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。
靶点	CB1	Human Endogenous Metabolite
体外研究	CB1 receptor stimulation increases brain Pregnenolone levels,which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC.Pregnenolone likely acts as a signalingspecific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands.Pregnenolone does not modify agonist binding but only agonist efficacy.The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100nM (15.1±1.8 % of inhibition).These effects are likely due to a pre-synaptic action of Pregnenolone.Thus,Pregnenolone blocks the increase in pairedpulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).
体内研究	Pregnenolone administration (2-6mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice,and blunts the memory impairment induced by THC in mice,but it does not modify these behaviors per se.Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.

推荐实验方法(仅供参考)

动物实验:

Mice and Rats

Adult male Wistar rats (weighing 320-340g),Sprague Dawley male rats (weighing 330-350g),C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30g at the beginning of the experiments) are used.Pregnenolone is injected subcutaneously (sc).The injection volumes are 1mL/kg of body weight for rats and 10mL/kg for mice.

保存条件：

-20℃ 充氮保存

UN码：

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危害声明：

安全说明：

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