PBOX 6 - CAS:290814-68-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	PBOX 6
英文名称:	PBOX 6
CAS No:	290814-68-5	分子式:	C₂₅H₂₀N₂O₃	分子量:	396.44
CAS No:	290814-68-5
分子式:	C₂₅H₂₀N₂O₃
分子量:	396.44

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

P10837 PBOX 6 ≥98% (psaitong)

相关产品

包装规格：

5mg 25mg in glass bottle

产品描述：

基本信息

产品编号：P10837
产品名称：PBOX 6
CAS:	290814-68-5	储存条件	粉末	-20℃	四年

分子式：	C25H20N2O3		溶于液体	-80℃	六个月
分子量	396.44			-20℃	一个月
化学名：
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

生物活性

产品描述	一种 pyrrolo-1,5-benzoxazepine (PBOX) 化合物，可作为微管解聚剂和促凋亡剂起作用。
靶点/IC₅₀	Apoptosis; Microtubule/Tubulin
体外研究	PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10μM in HL-60 cells.PBOX 6 (10μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cell.

推荐实验方法(仅供参考)

细胞实验:

Cells are seeded at a density of 3 × 105 cells/mL and following treatment with the indicated compound (including PBOX 6),an aliquot (100μL) is cytocentrifuged onto glass slides precoated with poly(l-lysine). They are then stained with the RapiDiff kit (eosin/methylene blue). The degree of apoptosis and necrosis is determined by counting 300 cells under a light microscope. At least three fields of view per slide, with an average of 100 cells per field, are counted and the percentage of apoptosis and necrosis is determined.Apoptotic cells are characterized by cell shrinkage, membrane blebbing, and nuclear condensation and fragmentation, whereas necrotic cells are identified by cell swelling and loss of cell membrane.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果