4-苯基丁酸钠盐 - CAS:1716-12-7 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	4-苯基丁酸钠盐促销
英文名称:	4-Phenylbutyrate
别名:	4-PBA Sodium phenylbutyrate 4-PBA Sodium phenylbutyrate
CAS No:	1716-12-7	分子式:	C₁₀H₁₁NaO₂	分子量:	186.18
CAS No:	1716-12-7
分子式:	C₁₀H₁₁NaO₂
分子量:	186.18
MDL:	MFCD00800247

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P10083 4-苯基丁酸钠盐 ≥98% (HPLC) (psaitong)

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熔点：

214-216°C

包装规格：

1g 5g in glass bottle

溶解性：

溶于水（25 mg/ml）和DMSO

产品描述：

一种HDAC（组蛋白去乙酰化酶)抑制剂,Ki;6.34μM。
Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. Sodium phenylbutyrate has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium Phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that Sodium Phenylbutyrate demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, this agent has been shown to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

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