| 中文名称: | 奥达特罗盐酸盐 | ||||
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| 英文名称: | Olodaterol hydrochloride | ||||
| 别名: | 盐酸奥达特罗 BI1744 hydrochloride | ||||
| CAS No: | 869477-96-3 | 分子式: | C21H27ClN2O5 | 分子量: | 422.9 |
| CAS No: | 869477-96-3 | ||||
| 分子式: | C21H27ClN2O5 | ||||
| 分子量: | 422.9 | ||||
基本信息
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产品编号： |
O70041 |
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产品名称： |
Olodaterol hydrochloride |
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CAS: |
869477-96-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
422.90 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
85mg/mL (200.99mM) |
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Ethanol |
85mg/mL (200.99mM) |
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Water |
85mg/mL (200.99mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.3646mL |
11.8231mL |
23.6463mL |
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5mM |
0.4729mL |
2.3646mL |
4.7293mL |
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10mM |
0.2365mL |
1.1823mL |
2.3646mL |
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50mM |
0.0473mL |
0.2365mL |
0.4729mL |
生物活性
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产品描述 |
一种选择性、长效的 β2-adrenoceptor (β2-AR) 激动剂。 |
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靶点 |
β2 adrenoceptor 0.1nM (EC50) |
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体外研究 |
Olodaterol hydrochloride (0.1~10nM;fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades.Olodaterol hydrochloride (0.001~10nM;fibroblasts) attenuates growth factor-induced motility and proliferation.Olodaterol hydrochloride (0.001~1000nM;0.5 hours;fibroblasts) increases intracellular cAMP in a concentration-dependent manner.Olodaterol hydrochloride (0~10nM;0.5 hours;fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70% at 10nM.Olodaterol hydrochloride has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes. Western Blot Analysis |
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Cell Line: |
Fibroblasts |
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Concentration: |
0.1~10nM |
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Result: |
Interfered with FGF-induced phosphorylation of signalling cascades. |
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Cell Proliferation Assay |
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Cell Line: |
Fibroblasts |
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Concentration: |
0.001~10nM |
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Result: |
Attenuated growth factor-induced motility and proliferation. |
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体内研究 |
Olodaterol (1mg/kg;inhal;21 days) accelerats body weights recovery back to control levels (at day 21) and attenuats TGFβ-induced lung fibrosis.Olodaterol (0.1~3μg/kg;inhal;5 hours) induces a dose-dependent bronchoprotection.Olodaterol (0.3 and 0.6μg/kg;inhal;24 hours) induces a maximal bronchoprotection of approximately 60% after 0.5 hours. |
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Animal Model: |
Lung fibrosis C57BL/6 mice |
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Dosage: |
1mg/mL |
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Administration: |
Inhal;21 days |
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Result: |
Accelerated body weight recovery back to control levels (at day 21) and attenuated TGF-βinduced lung fibrosis. |
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Animal Model: |
Guinea Pigs |
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Dosage: |
0.1~3μg/kg |
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Administration: |
Inhal;5 hours |
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Result: |
Induced a dose-dependent bronchoprotection. |
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Animal Model: |
Dogs |
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Dosage: |
0.3 and 0.6μg/kg |
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Administration: |
Inhal;24 hours |
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Result: |
Olodaterol (0.6μg/kg) induced a maximal bronchoprotection of approximately 60 % after 0.5h. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
