中文名称: | Olorinab | ||||
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英文名称: | Olorinab | ||||
别名: | APD 371 | ||||
CAS No: | 1268881-20-4 | 分子式: | C18H23N5O3 | 分子量: | 357.41 |
CAS No: | 1268881-20-4 | ||||
分子式: | C18H23N5O3 | ||||
分子量: | 357.41 |
基本信息
产品编号: |
O10256 |
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产品名称: |
Olorinab |
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CAS: |
1268881-20-4 |
储存条件 |
粉末 |
室温 |
四年 |
分子式: |
溶于液体 |
-80℃(密封储存) |
6个月 |
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分子量: |
357.41 |
-20℃(密封储存) |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.7979mL |
13.9895mL |
27.9791mL |
5mM |
0.5596mL |
2.7979mL |
5.5958mL |
10mM |
0.2798mL |
1.3990mL |
2.7979mL |
生物活性
产品描述 |
是大麻素受体 2 型 (CB2) 强有效的、选择性的全激动剂,其对 hCB2 的EC50 值为 6.2nM。 |
靶点 |
6.2nM (hCB2). |
体外研究 |
A comprehensive in vitro profile of Olorinab (APD 371) (6) shows that single digit nanomolar potency and full intrinsic efficacy are maintained in all species assessed,and that Olorinab (APD 371) is highly selective for CB2 over CB1 in both binding and functional assays.Furthermore,Olorinab (APD 371) induces efficient receptor internalization (~106% relative to the CB1/2 agonist CP55,940) in CHO cells expressing HA-tagged rat CB2 suggesting that,according to the hypothesis,Olorinab (APD 371) would be able to drive agonist-induced receptor recycling. |
体内研究 |
Olorinab (APD 371) significantly increases paw withdrawal thresholds at doses≥3mg/kg PO (ED50=2.3mg/kg).In a separate experiment,a single dose of Olorinab (APD 371) (10mg/kg,PO) inhibits paw withdrawal threshold for up to 4 hours after administration.Seperately,the analgesic effects of Olorinab (APD 371) are shown to be highly likely mediated via activity at CB2 receptors. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )