中文名称: | Oxiconazole nitrate | ||||
---|---|---|---|---|---|
英文名称: | Oxiconazole nitrate | ||||
别名: | 硝酸奥昔康唑 Ro 13-8996 | ||||
CAS No: | 64211-46-7 | 分子式: | C18H14Cl4N4O4 | 分子量: | 492.14 |
CAS No: | 64211-46-7 | ||||
分子式: | C18H14Cl4N4O4 | ||||
分子量: | 492.14 | ||||
EINEC: | 264-730-3 | ||||
EINEC: | 264-730-3 |
基本信息
产品编号:O10166 |
|||||
产品名称:Oxiconazole nitrate |
|||||
CAS: |
64211-46-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
六个月 |
||
分子量 |
492.14 |
-20℃ |
一个月 |
||
化学名: |
|||||
Solubility (25°C) |
体外 |
DMSO |
≥100mg/mL (203.19mM) |
||
Ethanol |
|
||||
Water |
|
||||
体内 |
现配现用 |
|
|||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.0319mL |
10.1597mL |
20.3194mL |
5mM |
0.4064mL |
2.0319mL |
4.0639mL |
10mM |
0.2032mL |
1.0160mL |
2.0319mL |
生物活性
产品描述 |
一种广谱抗真菌药物,可以抑制 T. tonsurans 和 T.rubrum 的生长 |
|
靶点/IC50 |
T. tonsurans MIC90: 0.25μg/mL |
T. rubrum 0.5μg/mL |
体外研究 |
Oxiconazole nitrate is the more active compound in tests with T. tonsurans and T. rubrum. Twelve isolates are inhibited by 0.063 μg/mL of oxiconazole; corresponding econazole MICs range from 0.063 (three isolates) to 8 (two isolates)μg/mL. Three isolates have oxiconazole MICs of 16 or 32μg/mL. |
|
体内研究 |
The baseline distortion product otoacoustic emission (DPOAE) results of the right ears of all animals tested are normal.Animals in groups I, II, IV and V show no statistically significant change in the DPOAE amplitudes. The rats in the gentamicingroup show a significant decrease. |
推荐实验方法(仅供参考)
细胞实验: |
|
Cell Assay |
A total of 121 isolates of pathogenic fungi are tested. The three drugs (including Oxiconazole nitrate) are serially diluted in sterile saline. For each test plate, 2mL of a solution of drug in sterile saline is added to an 18mL blank of molten agar medium at 50°C and mixed well; the resulting mixtures are then poured into the plates and allowed to solidify. The resulting drug dilution sequences range from 128 to 0.063μg/mL. Control plates are prepared in a similar manner using 2mL blanks of sterile saline. The plates are then inoculated using a replicator. Incubation is at 30°C for a minimum of 96 hr. The Minimal Inhibitory Concentration (MIC) is defined as the lowest concentration of drug producing complete inhibition of growth. |
动物实验: |
|
Animal Administration |
Fifty adult rats are divided into 5 groups consisting of 10 animals each. Over 14days, the rats in group I receive 0.1mL of Oxiconazole nitrate-containing solution drops, group II receives 4% boric acid solution in alcohol drops, and groups III and IV receive gentamicin (40mg/mL) and saline solutions, respectively. Group V receives no medication. Each solution used is given twice a day. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )