| 中文名称: | 奈多罗米 | ||||
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| 英文名称: | Nedocromil | ||||
| 别名: | 尼多克罗;奈多罗米;9-乙基-6,9-二氢-4,6-二氧代-10-丙基-4H-吡喃并[3,2-g]喹啉-2,8-二甲酸;尼多克罗,AR FPL 5900 | ||||
| CAS No: | 69049-73-6 | 分子式: | C19H17NO7 | 分子量: | 371.34 |
| CAS No: | 69049-73-6 | ||||
| 分子式: | C19H17NO7 | ||||
| 分子量: | 371.34 | ||||
基本信息
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产品编号： |
N10995 |
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产品名称： |
Nedocromil |
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CAS: |
69049-73-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
371.34 |
-20℃ |
1个月 |
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化学名： |
9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6929mL |
13.4647mL |
26.9295mL |
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5mM |
0.5386mL |
2.6930mL |
5.3859mL |
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10mM |
0.2693mL |
1.3465mL |
2.6930mL |
生物活性
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产品描述 |
抑制多种介质的作用或形成，包括组胺，白三烯 C4 (LTC4) 和前列腺素 D2 (PGD2)。 |
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靶点 |
LTC4 |
PGD |
Histamine |
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体外研究 |
Nedocromil inhibits the release of histamine,LTC4,and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1μM,2.3μM,and 1.9μM,respectively) and with anti-human IgE (IC30 values of 4.7μM,1.3μM,and 1.3μM,respectively). |
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体内研究 |
Nedocromil-treated diabetic mice show significantly improved heart function compared with controls.The contractility and relaxation forces show similar improvements.However,the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice.Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy,but the treatment cannot restore normal function. |
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推荐实验方法(仅供参考)
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动物实验: |
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Mice 8-12 weeks old C57/BL6 male mice between 23-25g receive intraperitoneal (i.p.) injections of 50mg/kg Streptozotocin (STZ),dissolved in 100mM citrate buffer pH 4.5,for five consecutive days.Diabetic mice (13-week-old) are randomly divided into three groups:1) untreated group;2) Nedocromil group,with Nedocromil released at the rate of 30mg/kg per day from a subcutaneous (s.c.) pellet implantation;and vehicle group,with an inactive pellet implanted.Normal mice (non-diabetic) and normal mice that receive Nedocromil (30mg/kg per day) are also included in this study for comparison.All sample groups included 15 mice (n=15). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
