中文名称: | NSC745885 | ||||
---|---|---|---|---|---|
英文名称: | NSC745885 | ||||
CAS No: | 4219-52-7 | 分子式: | C14H6N2O2S | 分子量: | 266.27 |
CAS No: | 4219-52-7 | ||||
分子式: | C14H6N2O2S | ||||
分子量: | 266.27 |
基本信息
产品编号:N10502 |
|||||
产品名称:NSC745885 |
|||||
CAS: |
4219-52-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
六个月 |
||
分子量 |
266.27 |
-20℃ |
一个月 |
||
化学名: |
|
||||
Solubility (25°C) |
体外 |
DMSO |
|
||
Ethanol |
|
||||
Water |
|
||||
体内(现配现用) |
|
|
|||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种有效的抗肿瘤 (anti-tumor) 试剂,对多种癌细胞株有选择性毒性,但对正常细胞没有毒性。 |
|
靶点/IC50 |
EZH2 |
|
体外研究 |
NSC745885 (0.5-4μM;24,48 or 72 hours) has a growth inhibitory or death-promoting effect on the SAS cells,it significantly decreases the densities of cultured cells when compared with untreated cells. The IC50 of NSC745885 is 0.85μM after 72 hours’treatment. NSC745885 (0.5-4μM; 24 hours) increases annexin V positive cells in a dose-dependent manner, and the differences appears as a dose-dependent manner. NSC745885 (0.5-2μM; 24 or 48 hours) decreases XIAP protein levels and increases protein levels both as a dose-dependent manner in SAS cells. |
|
Cell Line: |
SAS cells is obtained from a poorly differentiated human squamous cell carcinoma |
|
Concentration: |
0.5μM,1μM,1.5μM,2μM,4μM |
|
Incubation Time: |
24,48,or 72 hours |
|
Result: Decreases SAS cells growth as a time and dose-dependent manner. |
||
Apoptosis Analysis |
||
Cell Line: |
SAS cells is obtained from a poorly differentiated human squamous cell carcinoma |
|
Concentration: |
0.5μM,1μM,1.5μM,2μM,4μM |
|
Incubation Time: |
24 hours |
|
Result:
|
Decreases SAS cells growth as a time and dose-dependent manner. |
|
Western Blot Analysis |
||
Cell Line: |
SAS cells is obtained from a poorly differentiated human squamous cell carcinoma |
|
Concentration: |
0.5μM,1μM,1.5μM,2μM |
|
Incubation Time: |
24 or 48 hours |
|
Result:
|
Increased cleaved caspase-3 expression and decreased XIAP expression. |
|
体内研究 |
NSC745885 (intraperitoneal injection; 2mg/kg; once daily; 10 days) treatment significantly reduces tumor size when compared with the vehicle control, and exhibits a higher safety than doxorubicin. |
|
Animal Model: |
Eight-week-old NOD/SCID (NOD.CB17 Prkdcscid/J) mice |
|
Dosage: |
2mg/kg |
|
Administration: |
Intraperitoneal injection;2mg/kg;once daily;10 days |
|
Result: |
Inhibited engrafted tumors growth in vivo. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )