中文名称: | ML239 | ||||
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英文名称: | ML239 | ||||
别名: | (E)-N’-((1H-吡咯-2-基)亚甲基)-2-(2,4,6-三氯苯氧基)乙酰肼 (E)-N'-((1H-Pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide | ||||
CAS No: | 1378872-36-6 | 分子式: | C13H10Cl3N3O2 | 分子量: | 346.6 |
CAS No: | 1378872-36-6 | ||||
分子式: | C13H10Cl3N3O2 | ||||
分子量: | 346.6 |
一种有效的选择性的乳腺癌肿瘤干细胞抑制剂,C50 值为 1.16 μM。
ML239 is a potent and selective inhibitor of breast cancer stem cells. ML239 was best-in-class with an IC(50)= 1.18 µM against HMLE_sh_ECad, demonstrated a >23-fold selectivity over the control line, and was toxic to another CSC-like line, HMLE_shTwist, and a breast carcinoma cell line, MDA-MB-231. Gene expression studies conducted with ML239-treated cells showed altered gene expression in the NF-κB pathway in the HMLE_sh_ECad line but not in the isogenic control line.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )