MAO-IN-M30 dihydrochloride - CAS:64821-19-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	MAO-IN-M30 dihydrochloride 促销
英文名称:	MAO-IN-M30 dihydrochloride
别名:	MAO-IN-M30 dihydrochloride 5-((Methyl(prop-2-yn-1-yl)amino)methyl)quinolin-8-ol dihydrochloride
CAS No:	64821-19-8	分子式:	C14H14N2O.2HCl	分子量:	299.2
CAS No:	64821-19-8
分子式:	C₁₄H₁₄N₂O^.₂HCl
分子量:	299.2

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M50064 MAO-IN-M30 dihydrochloride ≥98% (普西唐-psaitong)

相关产品

包装规格：

5mg in glass bottle

溶解性：

溶于DMSO(≥20mg/mL）

产品描述：

基本信息

产品编号：	M50064
产品名称：	MAO-IN-M30 dihydrochloride
CAS:	64821-19-8	储存条件	粉末	-20℃	四年

分子式：	C14H14N2O.2HCl		溶于液体	-80℃	6个月
分子量	299.20			-20℃	1个月
化学名：	5-((Methyl(prop-2-yn-1-yl)amino)methyl)quinolin-8-ol dihydrochloride
Solubility (25°C)：
体外:	DMSO	2 mg/mL (6.68mM; ultrasonic and warming and heat to 60°C)
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度

溶液体积

质量

1mg

5mg

10mg

1mM

3.3422mL

16.7112mL

33.4225mL

5mM

0.6684mL

3.3422mL

6.6845mL

生物活性

产品描述	一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
靶点	MAO-A 37nM (IC50)	MAO-B 57nM (IC50)
体外研究	MAO-IN-M30 (0.25nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 (0-10μM; 24 hours) enhances PC12 cell survival. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells Cell Viability Assay
	Cell Line:	SH-SY5Y cells
	Concentration:	0.25nM
	Incubation Time:	72 hours
	Result:	Significantly increased cell viability to ∼90% after exposure to Dexamethasone.
	Cell Viability Assay
	Cell Line:	PC12 cells
	Concentration:	0-10μM
	Incubation Time:	24 hours
	Result:	Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
体内研究	MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities
	Animal Model:	Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)
	Dosage:	0.5, 2.5 mg/kg
	Administration:	P.o.; once daily for 14 consecutive days
	Result:	Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.