中文名称: | 1-脱氧半乳糖野尻霉素盐酸盐 | ||||
---|---|---|---|---|---|
英文名称: | Migalastat hydrochloride | ||||
别名: | 脱氧半乳糖野生霉素盐酸盐 Deoxygalactonojirimycin, Hydrochloride | ||||
CAS No: | 75172-81-5 | 分子式: | C6H13NO4 | 分子量: | 163.17 |
CAS No: | 75172-81-5 | ||||
分子式: | C6H13NO4 | ||||
分子量: | 163.17 |
包装规格:
5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介:
Migalastat hydrochloride (GR181413A) 是一种有效和竞争性的 α-galactosidase A 抑制剂,对人 α-Gal A 的 IC50 值为 0.04 μM。
储备液保存:
-80°C, 6 months; -20°C, 1 month
体内实验:
1、请依序添加每种溶剂: PBS
Solubility: 100 mg/mL (500.93 mM); Clear solution; Need ultrasonic
<1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
Solubility: 100 mg/mL (500.93 mM); Clear solution; Need ultrasonic
<1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
体外研究:
Both IC50 and Ki values of Migalastat hydrochloride (GR181413A) toward human lysosomal a-Gal A are 0.04 μM.
体内研究:
Fabry disease is an X-linked recessive disorder caused by the deficient activity of α-galactosidase A.
Migalastat (oral gavage, 3 mg/kg daily for 4 weeks) increases α-Gal A activity in heart, kidney, spleen, and liver in a dose- and time-dependently in transgenic mice that express human mutant alpha-Gal A (TgM).
Migalastat shows the half-life of less than 1 day in all major issues in TgM for 2 weeks pretreatment.
Migalastat (oral gavage, 100 mg/kg daily for 28 days) to transgenic mice reduces lyso-Gb3 levels up to 64%, 59%, and 81% in kidney, heart, and skin, respectively.
Migalastat (oral gavage, 3 mg/kg daily for 4 weeks) increases α-Gal A activity in heart, kidney, spleen, and liver in a dose- and time-dependently in transgenic mice that express human mutant alpha-Gal A (TgM).
Migalastat shows the half-life of less than 1 day in all major issues in TgM for 2 weeks pretreatment.
Migalastat (oral gavage, 100 mg/kg daily for 28 days) to transgenic mice reduces lyso-Gb3 levels up to 64%, 59%, and 81% in kidney, heart, and skin, respectively.
保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )