基本信息
产品编号: |
M11305 |
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产品名称: |
ML204 |
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CAS: |
5465-86-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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|
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
226.32 |
-20℃ |
1个月 |
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化学名: |
4-Methyl-2-(1-piperidinyl)-quinoline |
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Solubility (25°C): |
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体外:
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DMSO |
45mg/mL (198.83mM) |
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Ethanol |
45mg/mL (198.83mM) |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.4185mL |
22.0926mL |
44.1852mL |
5mM |
0.8837mL |
4.4185mL |
8.8370mL |
10mM |
0.4419mL |
2.2093mL |
4.4185mL |
生物活性
产品描述 |
一种有效的、选择性的TRPC4/TRPC5通道的抑制剂 |
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靶点 |
TRPC4 |
TRPC5 |
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体外研究 |
ML204 inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.ML204 blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin,and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors.ML204 blocks LPS-induced TRPC5 channel activity. |
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体内研究 |
ML204 (1mg/kg; s.c.;twice a day;for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice. |
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Animal Model: |
Nonfasted male C57BL/6 (2-3 months) |
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Dosage: |
1mg/kg |
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Administration: |
Subcutaneous injection,twice a day,for 5 days (prior to LPS injection) |
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Result: |
Induced mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )