中文名称: | 2'MeO6MF | ||||
---|---|---|---|---|---|
英文名称: | 2'MeO6MF | ||||
别名: | 2'MeO6MF 2'MeO6MF | ||||
CAS No: | 89112-85-6 | 分子式: | C17H14O3 | 分子量: | 266.29 |
CAS No: | 89112-85-6 | ||||
分子式: | C17H14O3 | ||||
分子量: | 266.29 |
基本信息
产品编号: |
M11269 |
||||
产品名称: |
2'MeO6MF |
||||
CAS: |
89112-85-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
二年 |
||
分子量: |
266.29 |
|
|
||
化学名: |
|||||
Solubility (25°C): |
|||||
体外:
|
DMSO |
|
|||
Ethanol |
|
||||
Water |
|
||||
体内(现配现用): |
|
||||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种可透过血脑屏障的α2β1γ2L和所有含α1的GABAA受体的正变构调节剂。2'MeO6MF也可以直接激活α2β2/3和α2β2/3γ2LGABAA受体。2'MeO6MF具有抗焦虑和镇静作用。2'MeO6MF可提供神经保护作用并改善功能恢复,还可抑制中风诱发的炎症反应。 |
|
靶点 |
GABAA receptor |
|
体外研究 |
2'MeO6MF (100-300µM;60 min) weakly displaces [3H]-flunitrazepam binding to rat brain synaptosomal membranes by 5-10%.2'MeO6MF enhances [3H]-muscimol binding to rat brain synaptic membranes in a concentration-dependent manner yielding a mean Emax of 219.8% and apparent EC50=20.8nM.2'MeO6MF (1-300µM) enhances the response elicited by a low concentration of GABA in a concentration-dependent manner at recombinant α1β2γ2L GABAA receptors expressed in XenopusM oocytes.2'MeO6MF enhances the response elicited by GABA at recombinant α1β1,3γ2L and α1β2 GABAA receptors without any direct activation.2'MeO6MF (1-10µM;60 min) increases tonic inhibitory currents in a concentration-dependent manner in granule cells.2'MeO6MF (100-1000µM;6.5h) inhibits the LPS-induced increase of NFkB activity in RAWblueTM macrophage cells. |
|
体内研究 |
2'MeO6MF (1-100mg/kg;i.p.) displays anxiolytic-like effects in the elevated plus maze and light/dark tests.2'MeO6MF induces sedative effects at higher doses in the holeboard,actimeter and barbiturate-induced sleep time tests.2'MeO6MF (30mg/kg;i.p.) increases tonic currents in layer 2/3 pyramidal neurons of mice after stroke.2'MeO6MF (0.1-30mg/kg;i.p.) is neuroprotective and enhances functional recovery after focal cerebral ischaemia in mice. |
|
Animal Model: |
Male Balb-c mice (8-10 weeks,25-35g) |
|
Dosage: |
1,10,30,100mg/kg |
|
Administration: |
I.p. |
|
Result: |
No overt acute toxicity was observed.Exerted anxiolytic effects at low doses and sedative effects at high doses without myorelaxant effects. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )