| 中文名称: | MYCMI-6 促销 | ||||
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| 英文名称: | MYCMI-6 | ||||
| 别名: | NSC354961 | ||||
| CAS No: | 681282-09-7 | 分子式: | C20H19N7O | 分子量: | 373.41 |
| CAS No: | 681282-09-7 | ||||
| 分子式: | C20H19N7O | ||||
| 分子量: | 373.41 | ||||
基本信息
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产品编号：M10787 |
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产品名称：MYCMI-6 |
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CAS: |
681282-09-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
373.41 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6780mL |
13.3901mL |
26.7802mL |
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5mM |
0.5356mL |
2.6780mL |
5.3560mL |
生物活性
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产品描述 |
一种有效的选择性内源性 MYC:MAX 蛋白相互作用抑制剂。 |
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靶点/IC50 |
c-Myc |
Apoptosis |
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体外研究 |
MYCMI-6 (NSC354961) (6.25μM; 48 hours) selectively suppresses MYC-driven tumor cell growth with high efficacy.MYCMI-6 significantly inhibits growth of Burkitt’s lymphoma cells (Mutu,Daudi and ST486) - another classical example of a MYC-driven tumor, having translocations of MYC to one of the immunoglobulin loci - in a dose-dependent manner with an average GI50 of 0.5μM.Treatment of MCF7 cells with the MYCMI-6 for 24 hours significantly decreased MYC:MAX isPLA signals to 7%. Titration showed an IC50 for inhibition of MYC:MAX of less than 1.5μM for MYCMI-6 by isPLA. MYCMI-6 inhibits the MYC:MAX heterodimer formation with an IC50 of 3.8μM.MYCMI-6 efficiently inhibits anchorage-independent growth of MYCN-amplified neuroblastoma cells with GI50 values of <0.4μM. |
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Cell Line: |
MYCN-amplified neuroblastoma cells (IMR-32, Kelly and SK-N-DZ), MYCN-non-amplified neuroblastoma cells (SK-N-F1, SK-N-AS and SK-N-RA) |
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Concentration: |
6.25μM |
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Incubation Time: |
48 hours |
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Result: |
Result: Reduced growth of the MYCN-amplified cell lines significantly stronger than the MYCN-nonamplified cell lines. |
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体内研究 |
MYCMI-6 (20mg/kg; i.p.; daily for 1-2 weeks) induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model. |
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Animal Model: |
6-8 weeks old athymic nude mice (bearing MYCN-amplified SK-N-DZ neuroblastoma cells) |
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Dosage: |
20 mg/kg body weight |
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Administration: |
I.p.; daily for 1-2 weeks |
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Result: |
A dramatic increase in the extension of apoptotic areas in the tumors and a significant increase in non-proliferative areas as determined by Ki67 staining in tumors. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
