中文名称: | MMAD | ||||
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英文名称: | MMAD | ||||
别名: | 单甲基澳瑞他汀 D Demethyldolastatin 10;(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide | ||||
CAS No: | 203849-91-6 | 分子式: | C41H66N6O6S | 分子量: | 771.08 |
CAS No: | 203849-91-6 | ||||
分子式: | C41H66N6O6S | ||||
分子量: | 771.08 |
基本信息
产品编号:M10477 |
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产品名称:MMAD |
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CAS: |
203849-91-6 |
储存条件 |
粉末 |
-20℃
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四年 |
分子式: |
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分子量: |
771.08 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.2969mL |
6.4846mL |
12.9692mL |
5mM |
0.2594mL |
1.2969mL |
2.5938mL |
10mM |
0.1297mL |
0.6485mL |
1.2969mL |
生物活性
产品描述 |
一种有效的微管tubulin抑制剂,是抗体药物偶联物(ADCs)中的活性分子。 |
靶点/IC50 |
Auristatin |
体外研究 |
MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties,potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity. |
体内研究 |
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )