米卡芬静钠 - CAS:208538-73-2 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	米卡芬静钠
英文名称:	Micafungin sodium
别名:	米卡芬净钠 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 sodium salt
CAS No:	208538-73-2	分子式:	C₅₆H₇₀N₉O₂₃S^.Na	分子量:	1292.26
CAS No:	208538-73-2
分子式:	C₅₆H₇₀N₉O₂₃S^.Na
分子量:	1292.26

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M10090 米卡芬静钠 ≥98%(HPLC) (psaitong)

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包装规格：

5mg 25mg 100mg in glass bottle

溶解性：

溶于水（2mg/mL 加热）和DMSO。

产品描述：

基本信息

产品编号：M10090
产品名称：Micafungin sodium
CAS:	208538-73-2	储存条件	粉末	-20℃（避光）	四年
分子式：	C56H70N9O23S.Na		溶于液体	-80℃（避光）	两年
分子量	1292.26			-20℃（避光）	一个月
化学名：	sodium;[5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[[4-[5-(4-
Solubility (25°C)	体外	DMSO	100mg/mL warmed with 50ºC water bath (77.38mM)
		Ethanol	Insoluble
		Water	100mg/mL (77.38mM)
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	0.7738mL	3.8692mL	7.7384mL
5mM	0.1548mL	0.7738mL	1.5477mL
10mM	0.0774mL	0.3869mL	0.7738mL
50mM	0.0155mL	0.0774mL	0.1548mL

生物活性

产品描述	一种半合成的棘皮坎丁抗真菌药，通过抑制β（1,3）-D-葡聚糖合成酶，从而干扰真菌细胞壁的完整性。
靶点/IC₅₀	Fungal	Antibiotic
体外研究	Micafungin (10mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone.
体内研究	Micafungin (1mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1mg/kg) and KB425796-C (32mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPHtreated animals.

推荐实验方法(仅供参考)

细胞实验:

Cell Assay

Each fungal isolate is incubated statically in yeast-maltose (YM) agar broth for 24 h at 30°C. Cryptococcus neoformans YC203 is grown in YM broth medium for 20 h at 30°C with shaking at 200 r.p.m. A cell suspension is prepared by washing the cultured cells once with sterile saline. A. fumigatus FP1305 is cultured on a potato dextrose agar (PDA) slant for 4 days, and spores are then harvested in sterile saline and collected by filtering through gauze. Antifungal activity against all isolates,with the exception of C. neoformans, is measured by the micro-broth dilution method in 96-well culture plates using RPMI 1640 medium supplemented with l-glutamine, but without sodium bicarbonate, and buffered to pH 7.0 with 0.165 m MOPS. ForC. neoformans, yeast nitrogen base-glucose (YNBD) medium is used. For the assay, the test microorganism is inoculated

into each well to yield 1×105 CFU/well, and the plates are then incubated for 20 h or 48 h at 37°C. Two end points are determined by microscopic observation: MEC, which is defined as a substantial reduction in fungal growth, and MIC, which is defined as a complete inhibition of growth.

动物实验:

Animal Administration

Eight groups of ten female DBA/2 mice (7weeks old) are intravenously injected with 2.0×106 A. fumigatus FP1305 spores.The test groups receive the following treatments: AMPH at 1mg/kg of body weight/dose given intraperitoneally (i.p.) once daily (q.d.); micafungin at 0.1, 0.32 or 1mg/kg of body weight/dose given subcutaneously (s.c.) (q.d.); micafungin given s.c.(0.1, 0.32 or 1mg/kgq.d.) plus KB425796-C given i.p. (32mg/kg) twice daily (b.i.d.); and saline (b.i.d.). Drugs are administered on days 1 and 2. Five mice in each group are killed 1 day after the completion of treatment. The livers and kidneys are aseptically removed, and each organ is then homogenized in 5mL sterile saline. Serial 10-fold dilutions of the homogenates are plated on PDA and incubated for 48h at 37°C, and the numbers of CFU per gram of tissue are then calculated. The survival rate of remaining five mice of each group are examined daily for 31days after the challenge.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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