| 中文名称: | L48H37 | ||||
|---|---|---|---|---|---|
| 英文名称: | L48H37 | ||||
| 别名: | 1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one;(3E,5E)-1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one | ||||
| CAS No: | 343307-76-6 | 分子式: | C27H33NO7 | 分子量: | 483.55 |
| CAS No: | 343307-76-6 | ||||
| 分子式: | C27H33NO7 | ||||
| 分子量: | 483.55 | ||||
包装规格：
2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：
L48H37 是一种化学稳定性提高了的姜黄素 (HY-N0005) 类似物。L48H37 是一种有效且特异性的髓系分化蛋白 2 (MD2) 抑制剂，抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 用于脓毒症或肺损伤的相关研究。
溶解性：
DMSO :50 mg/mL (103.40 mM; Need ultrasonic)
储备液保存：
-80°C, 6 months
-20°C, 1 month
(protect from light)
-20°C, 1 month
(protect from light)
靶点：
TLR4
体外研究：
L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages.
L48H37 (0-20 µM; 24 hours) decreases the viability of A549 and H460 cells with IC50 values of 5.3 µM and 2.3 µM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC50 of 21 μM.
L48H37 (1, 2, or 4 µM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells.
L48H37 (4 µM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells.
L48H37 (0-20 µM; 24 hours) decreases the viability of A549 and H460 cells with IC50 values of 5.3 µM and 2.3 µM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC50 of 21 μM.
L48H37 (1, 2, or 4 µM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells.
L48H37 (4 µM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells.
体内研究：
L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice.
保存条件：
2-8°C 避光
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
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参考文献 & 客户发表文献
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质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
