| 中文名称: | LY2794193 | ||||
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| 英文名称: | LY2794193 | ||||
| 别名: | (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | ||||
| CAS No: | 2173037-97-1 | 分子式: | C16H18N2O6 | 分子量: | 334.32 |
| CAS No: | 2173037-97-1 | ||||
| 分子式: | C16H18N2O6 | ||||
| 分子量: | 334.32 | ||||
基本信息
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产品编号： |
L11028 |
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产品名称： |
LY2794193 |
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CAS: |
2173037-97-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
334.32 |
-20℃ |
1个月 |
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化学名： |
(1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.9911mL |
14.9557mL |
29.9115mL |
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5mM |
0.5982mL |
2.9911mL |
5.9823mL |
生物活性
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产品描述 |
一种高效的选择性 mGlu3 受体激动剂。 |
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靶点 |
mGluR3 0.47nM (EC50) |
mGluR3 0.927nM (Ki) |
mGluR2 47.5 (EC50) |
mGluR2 412 (Ki) |
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体外研究 |
LY2794193 exhihits inhibition of spontaneous Ca2+oscillations in cultured rat cortical neurons with an EC50 of 43.6nM.In the rat cortical neuron Ca2+oscillation assay,LY2794193 exhibits a biphasic inhibition of spontaneous Ca2+transients (high affinity EC50=0.44nM;48% of the total agonist response;low affinity EC50=43.6nM;52% of the total agonist response) with combined maximal agonist efficacy (Emax) of 66%. |
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体内研究 |
LY2794193 (1-30mg/kg,s.c.),given 30 min prior to PCP (5mg/kg,s.c.) leads a dose-related reduction in ambulations.LY2794193 (1mg/kg;i.v.) exhibits moderate clearance (18.3mL/min per kg) and volume of distribution (1.17L/kg) with a calculated plasma half-life (T1/2) of 3.1 h in Male Sprague-Dawley rats.LY2794193 (3mg/kg;s.c.) leads to the rapid appearance in the plasma (AUC=9.9μM;Cmax=6.78μM;Tmax=0.44h) and a calculated bioavailability of 121% in male Sprague-Dawley rats. |
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Animal Model: |
Male Sprague-Dawley rats |
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Dosage: |
1,3,10,or 30mg/kg |
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Administration: |
Administrated s.c.;given 30 min prior to PCP (5mg/kg,s.c.) |
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Result: |
A dose-related reduction in ambulations was observed,with the 10 and 30mg/kg dose groups found to be statistically significant. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
