中文名称: | LY341495 | ||||
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英文名称: | LY341495 | ||||
别名: | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine | ||||
CAS No: | 201943-63-7 | 分子式: | C20H19NO5 | 分子量: | 353.37 |
CAS No: | 201943-63-7 | ||||
分子式: | C20H19NO5 | ||||
分子量: | 353.37 |
基本信息
产品编号: |
L11024 |
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产品名称: |
LY341495 |
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CAS: |
201943-63-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
353.37 |
-20℃ |
1个月 |
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化学名: |
2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.8299mL |
14.1495mL |
28.2990mL |
5mM |
0.5660mL |
2.8299mL |
5.6598mL |
10mM |
0.2830mL |
1.4149mL |
2.8299mL |
生物活性
产品描述 |
一种代谢型谷氨酸受体 (mGluR) 拮抗剂。 |
靶点 |
mGluR |
体内研究 |
LY341495 (0.3,1,and 3mg/kg,i.p.) displays a lower level of discrimination in rats.LY341495 (3.0mg/kg) decreases Dvl-2,pGSK-3α/β and β-catenin protein levels but Dvl-1,Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR.LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist,LY379268.LY341495 (3mg/kg,i.p.,2.5h) -induced c-Fos expression is not altered in either KO brain.LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala,lateral (CeL) and bed nucleus of the stria terminalis,laterodorsal (BSTLD)] in mGluR3-KO mice. |
推荐实验方法(仅供参考)
动物实验: |
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The rats are randomLy divided into six experimental groups (10 rats per group):vehicle and 0.05,0.1,0.3,1,and 3mg/kg LY341495.The LY341495 doses are selected on the basis of results from previous Published studies that evaluated the effects of this compound on cognition.The rats are subjected to a training session that consisted of two 2-min trials.The animals receive either vehicle or LY341495 immediately after T1.Using the 2-min trial duration,an ITI of 1h is used because recognition memory is still intact in untreated control rats under these experimental conditions. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )