| 中文名称: | Ladostigil | ||||
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| 英文名称: | Ladostigil | ||||
| 别名: | Ladostigil (R)-3-(Prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-5-yl ethyl(methyl)carbamate;TV-3326 | ||||
| CAS No: | 209394-27-4 | 分子式: | C16H20N2O2 | 分子量: | 272.34 |
| CAS No: | 209394-27-4 | ||||
| 分子式: | C16H20N2O2 | ||||
| 分子量: | 272.34 | ||||
基本信息
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产品编号： |
L11007 |
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产品名称： |
Ladostigil |
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CAS: |
209394-27-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
272.34 |
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化学名： |
(R)-3-(Prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-5-yl ethyl(methyl)carbamate |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种胆碱酯酶 (cholinesterase) 和脑选择性单胺氧化酶 (MAO) 的双重抑制剂，抑制 MAO-B 和 AChE 的 IC50 值分别为 37.1 和 31.8μM。Ladostigil 能够增加胆碱能的传递，防止 ROS 的形成或其作用，可用于抑郁症和阿尔茨海默氏病的研究。 |
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靶点 |
MAO-B 37.1μM (IC50) |
AChE 31.8μM (IC50) |
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体外研究 |
Ladostigil (1-10 µM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults . Ladostigil (1-10 µM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells . |
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体内研究 |
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats. Ladostigil (50μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats |
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Animal Model: |
Pathogen-free (SPF) Sprague-Dawley rats |
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Dosage: |
17 mg/kg |
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Administration: |
P.o. (added to the drinking water) daily for 6 weeks |
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Result: |
Inhibited brain MAO-A and B by more than 60%. Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
