Lemildipine - CAS:94739-29-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Lemildipine
英文名称:	Lemildipine
别名:	来米地平 NB-818;NPK-1886
CAS No:	94739-29-4	分子式:	C₂₀H₂₂Cl₂N₂O₆	分子量:	457.3
CAS No:	94739-29-4
分子式:	C₂₀H₂₂Cl₂N₂O₆
分子量:	457.3

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L10495 Lemildipine ≥98% (psaitong)

相关产品

包装规格：

5mg in glass bottle

溶解性：

溶于DMSO(100mg/ml超声)

产品描述：

基本信息

产品编号：	L10495
产品名称：	Lemildipine
CAS:	94739-29-4	储存条件	粉末	-20℃	四年

分子式：	C20H22Cl2N2O6		溶于液体	-80℃	6个月
分子量：	457.30			-20℃	1个月
化学名：	5-O-methyl 3-O-propan-2-yl 2-(carbamoyloxymethyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.1867mL	10.9337mL	21.8675mL
5mM	0.4373mL	2.1867mL	4.3735mL
10mM	0.2187mL	1.0934mL	2.1867mL

生物活性

产品描述	一种钙通道阻滞剂。
靶点	Calcium entry
体内研究	Gerbils are treated intraperitoneally with Lemildipine (0.1-3mg/kg) just after release of the occlusion.Four days after the ischemia,they are fixed by perfusing 10% buffered-formalin,and the neuronal cell density (NCD,cell/mm) in the CA1 subfield is estimated under microscopy.The average NCD in the ischemic control group is 43±10.8 cells/mm,whereas Lemildipine (3mg/kg) significantly ameliorates DND with an average NCD of 143±24.2 cells/mm (P<0.01).In addition,Lemildipine (3mg/kg) significantly inhibits delayed neuronal death (DND) at 1,2 and 4 weeks after transient ischemia:the average NCD of the Lemildipine and ischemic control groups are 80±9.4 (P<0.01) and 43±7.7 cells/mm,92±13.7 (P<0.05) and 52±9.3 cells/mm,and 57±5.0 (P<0.01) and 43±12.4 cells/mm,respectively.In this experiment,Lemildipine (NB-818) exhibits a protective effect on DND in the hippocampal CA1 subfield after transient forebrain ischemia, and its effect persisted for up to 4 weeks.In normal Wistar rats (NWR),Lemildipine (NPK-1886) in doses of 3-30mg/kg,p.o.,produces a mild lowering of blood pressure.The depressor effect of Lemildipine is much the same as that of Nifedipine. In contrast,Lemildipine produces a significant decrease in the blood pressure of spontaneously hypertensive rats (SHR).Oral administration of Lemildipine in doses of 3,10,30mg/kg produces a significant decrease in systolic blood pressure dose-dependently.The maximum decrease is observed 1-3hr after administration.Comparing the hypotensive potency of Lemildipine and Nifedipine,their dose-response curves at the maximum response during the observation (for 24hr) are analyzed by the least squares method,and the dose of 30% decrease in blood pressure from the control level (ED30) are used as a measure of their potency.Lemildipine is 1.4 times stronger than Nifedipine;the ED30 values of Lemildipine and Nifedipine are 10.2mg/kg and 14.3mg/kg,respectively.

推荐实验方法(仅供参考)

动物实验:

Gerbils

Male Mongolian gerbils,weighing 50-80g,are used in this experiment.Lemildipine (3mg/kg) or vehicle is administered intraperitoneally just after the recirculation. At 1,2 or 4 weeks after ischemia,the animals are sacrificed,and the protective effect of Lemildipine (NB-818) is examined.

Mice and Rats

Normal Wistar rats (NWR) and hypertensive model rats (spontaneously hypertensive rats (SHR),renal hypertensive rats (RHR) and DOCA-saline-induced hypertensive rats (DOC-Na-R)) of the male sex, weighing from 250 to 350g,are used.Oral administration of Lemildipine in doses of 3,10,30mg/kg for normal Wistar rats (NWR).Lethal dose of Lemildipine and Nifedipine is determined by the Litchfield-Wilcoxon method from the data of experiments using healthy mice and rats.Mice (male and female) weighing 20±2g and male rats weighing from 150 to 220g are used.These two kinds of animals are fed on solid food (Crea,CA-1) and water ad lib.The animal room temperature and humidity are controlled at 22±2℃ and 55±5%,respecttively.No food except water is administered 24hr before starting the experiments for oral administration of drugs.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果