中文名称: | 洛度沙胺氨丁三醇 | ||||
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英文名称: | Lodoxamide tromethamine | ||||
别名: | 洛度沙胺氨丁三醇 U-42585E | ||||
CAS No: | 63610-09-3 | 分子式: | C15H17ClN4O9 | 分子量: | 553.9 |
CAS No: | 63610-09-3 | ||||
分子式: | C15H17ClN4O9 | ||||
分子量: | 553.9 |
基本信息
产品编号: |
L10458 |
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产品名称: |
Lodoxamide tromethamine |
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CAS: |
63610-09-3 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
553.90 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
Insoluble |
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Ethanol |
Insoluble |
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Water |
19mg/mL (34.3mM) |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.8054mL |
9.0269mL |
18.0538mL |
5mM |
0.3611mL |
1.8054mL |
3.6108mL |
10mM |
0.1805mL |
0.9027mL |
1.8054mL |
生物活性
产品描述 |
作为肥大细胞稳定剂的抗过敏化合物, 用于研究哮喘和过敏性结膜炎。 |
靶点 |
Histamine Receptor |
体外研究 |
lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells. |
体内研究 |
Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys.When given intravenously,orally,or intrabronchially by aerosol,lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized.anesthetized rhesus monkeys.Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation,decreased microvascular permeability,and increased compliance.Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty,cough,sputum production,and sleep. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )