| 中文名称: | L755507 | ||||
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| 英文名称: | L755507 | ||||
| 别名: | 4-[[(己基氨基)羰基]氨基]-N-[4-[2-[[(2S)-2-羟基-3-(4-羟基苯氧基)丙基]氨基]乙基]苯基]苯磺酰胺 1-hexyl-3-[4-[[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]sulfamoyl]phenyl]urea | ||||
| CAS No: | 159182-43-1 | 分子式: | C30H40N4O6S | 分子量: | 584.73 |
| CAS No: | 159182-43-1 | ||||
| 分子式: | C30H40N4O6S | ||||
| 分子量: | 584.73 | ||||
基本信息
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产品编号： |
L10374 |
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产品名称： |
L755507 |
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CAS: |
159182-43-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
584.73 |
-20℃ |
1个月 |
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化学名： |
Benzenesulfonamide,4-[[(hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]- |
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Solubility (25°C)： |
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体外:
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DMSO |
100mg/mL (171.01mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.7102mL |
8.5510mL |
17.1019mL |
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5mM |
0.3420mL |
1.7102mL |
3.4204mL |
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10mM |
0.1710mL |
0.8551mL |
1.7102mL |
生物活性
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产品描述 |
一个有效的,选择性强的 β3-AR 激动剂,其 IC50 值为 35nM。 |
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靶点 |
β3 adrenergic receptor |
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0.43nM(EC50) |
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体外研究 |
L755507 causes a robust concentration-dependent increase in cAMP accumulation (pEC50 values of 8.5 and 12.3,respectively).Maximal cAMP accumulation with zinterol and L755507 is increased after pretreatment with pertussis toxin.In contrast to cAMP,zinterol,L755507 and L748337 increase phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) with very high potency (pEC50 values of 10.9,11.7 and 11.6).L755507 and Scr7 do not reduce cell viability significantly.Scr7 does not affect cell cycle distribution in a range of 10 to 200μM.L755507 significantly decreases the proportion of cells in the G2/M phase at 10μM or 40μM and increases the S-phase cells at 10μM compare with the DMSOtreated cells. |
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体内研究 |
对rhesus monkeys施以短时间L-755,507处理，其脂类分解和代谢速率提高。而长期处理则增加其褐色脂肪组织中解偶联蛋白1的表达。 |
推荐实验方法(仅供参考)
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细胞实验: |
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The cytosensor microphysiometer is used to measure β3-AR-mediated increases in ECAR .In brief,CHO β3 cells are seeded into 12-mm Transwell inserts at 5×105 cells/cup and left to adhere overnight.On the day of experiment,cells are equilibrated for 2h,and cumulative concentration-response curves to L755507,zinterol,or L748337 are constructed in paired sister cells with each concentration of drug exposed to cells for 14 min.Results are expressed as a percentage of the maximal response to L755507.In experiments examining the effect of inhibitors,cells are treated for 30 min before stimulation with appropriate drugs.All drugs are diluted in modified RPMI 1640 medium.These results are expressed as a percentage of the maximal response to L755507,zinterol,or L748337 over basal. |
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动物实验: |
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动物模型 |
Male lean rhesus monkeys |
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剂量 |
3mg/kg |
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给药处理 |
静脉注射 |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
