Lu AF21934 - CAS:1445605-23-1 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Lu AF21934
英文名称:	Lu AF21934
别名:	mGluR LuAF21934;(1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide
CAS No:	1445605-23-1	分子式:	C₁₄H₁₆Cl₂N₂O₂	分子量:	315.19
CAS No:	1445605-23-1
分子式:	C₁₄H₁₆Cl₂N₂O₂
分子量:	315.19

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L10170 Lu AF21934 ≥98%(HPLC) (psaitong)

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包装规格：

5mg 25mg 100mg in glass bottle

溶解性：

溶于DMSO(≥80mg/mL)

产品描述：

基本信息

产品编号：	L10170
产品名称：	Lu AF21934
CAS:	1445605-23-1	储存条件	粉末	-20℃	四年

分子式：	C14H16Cl2N2O2		溶于液体	-80℃	6个月
分子量：	315.19			-20℃	1个月
化学名：	(1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.1726mL	15.8629mL	31.7259mL
5mM	0.6345mL	3.1726mL	6.3452mL
10mM	0.3173mL	1.5863mL	3.1726mL

生物活性

产品描述

一种mGlu4受体的正变构调节剂。

靶点

mGlu4 Receptor

500nM (EC50)

体内研究

Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia,four-plate,and marble-burying tests.The anti-hyperthermic effect of Lu AF21934 (5mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10mg/kg) and is not serotonin dependent.Lu AF21934 does not produce antidepressantlike effects in the tail suspension test in mice;however,it decreases the basal locomotor activity of mice that are not habituated to activity cages.Lu AF21934 (0.5-5mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5mg/kg reverses harmaline-induced hyperactivity.Lu AF21934 at a dose of 2.5mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmalineincreased basic activity during the period of 30-90 min.Lu AF21934 (0.1-5mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine.It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices,induced by DOI.

推荐实验方法(仅供参考)

动物实验:

Rats:Lu AF21934 is dispersed in 20% (2-hydropropyl)-b-cyclodextrin and are administered subcutaneously (s.c.) 60 min before the test.Lu AF21934 (2,5,10 and 15mg/kg,s.c.) and diazepam (5mg/kg,i.p.) are administered acutely 1h before the Vogel’s conflict test.The effects of each drug in all experiments are measured in groups of 8-10 animals.

Mice:Lu AF21934 is dispersed in 20% (2-hydropropyl)-b-cyclodextrin and are administered subcutaneously (s.c.) 60 min before the test.Mice are gently placed into the box and allowed to explore for 15s.Then,each time a mouse passed from one plate to another,the experimenter electrifies the whole floor thus evoking a visible flight reaction of the animal.If the animal continues running,no new shock is delivered for the following 3s.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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