中文名称: | 蔗糖铁 | ||||
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英文名称: | Iron sucrose | ||||
别名: | 蔗糖铁 Iron saccharate | ||||
CAS No: | 8047-67-4 | 分子式: | C18H24Fe2O24 | 分子量: | 736.1 |
CAS No: | 8047-67-4 | ||||
分子式: | C18H24Fe2O24 | ||||
分子量: | 736.1 | ||||
EINEC: | 232-464-7 | ||||
EINEC: | 232-464-7 |
基本信息
产品编号: |
I60011 |
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产品名称: |
Iron sucrose |
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CAS: |
8047-67-4 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
736.10 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
100mg/mL (135.85mM) |
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Ethanol |
Insoluble |
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Water |
100mg/mL (135.85mM) |
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体内(现配现用): |
1.请依序添加每种溶剂:10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 3mg/mL (InfinitymM); Clear solution |
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此⽅案可获得 ≥ 3mg/mL (InfinitymM,饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例,取 100μL 30.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中,混合均匀;向上述体系中加⼊ 50μL Tween-80,混合均匀;然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 |
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2.请依序添加每种溶剂:10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 3mg/mL (InfinitymM); Clear solution |
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此⽅案可获得 ≥ 3mg/mL (InfinitymM,饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例,取 100μL 30.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.3586mL |
6.7929mL |
13.5858mL |
5mM |
0.2717mL |
1.3586mL |
2.7172mL |
10mM |
0.1359mL |
0.6793mL |
1.3586mL |
50mM |
0.0272mL |
0.1359mL |
0.2717mL |
生物活性
产品描述 |
一种静脉注射铁制剂和一种促氧化剂。Iron sucrose 可用于缺铁性贫血的研究。 |
体外研究 |
Intravenous Iron sucrose results in a statistically significant increase in hemoglobin, mean corpuscular volume, serum iron, ferritin, and % iron saturation, with a corresponding decrease in total iron binding capacity. In vitro survival assays show that 10mM ascorbate exposure (2h) clonogenically inactivated 40-80% of exponentially growing colon cancer cell lines (HCT116 and HT29). When colon cancer cells are treated in the presence or absence of 250 µM Iron sucrose, then rinsed, and treated with 10mM ascorbate, the cells demonstrate increased levels of labile iron that results in significantly increased clonogenic cell killing, compared to pharmacological ascorbate alone. The expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in Iron sucrose-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-κB signaling. Iron sucrose significantly induces a time-dependent increase in intracellular ROS production in HAECs between 1 and 3 hours at a concentration of 160 μg/mL, but the effect diminished at 4 hours |
体内研究 |
Iron sucrose significantly increases tissue superoxide production, expression of tissue cell adhesion molecules, and endothelial adhesiveness in mice with subtotal nephrectomy. Iron sucrose exacerbates atherosclerosis in the aorta of ApoE- /- mice with uninephrectomy |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )