中文名称: | Iganidipine | ||||
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英文名称: | Iganidipine | ||||
别名: | 伊加地平 | ||||
CAS No: | 119687-33-1 | 分子式: | C28H38N4O6 | 分子量: | 526.62 |
CAS No: | 119687-33-1 | ||||
分子式: | C28H38N4O6 | ||||
分子量: | 526.62 |
基本信息
产品编号: |
I10349 |
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产品名称: |
Iganidipine |
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CAS: |
119687-33-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
一年 |
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分子量: |
526.62 |
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化学名: |
5-O-[2,2-dimethyl-3-(4-prop-2-enylpiperazin-1-yl)propyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种钙离子通道拮抗剂。 |
靶点 |
Ca2+ |
体内研究 |
Iganidipine (0.03% solution) significantly increases optic nerve head (ONH) tissue blood velocity (NBONH) by 8 to 10% in treated eyes after a single administration (p<0.05) or by 18 to 35% after 7-,14-,or 21-day twicedaily administration in rabbits (p<0.05).In monkeys,0.03% and 0.1% Iganidipine significantly increases NBONH in treated eyes by 20 and 41% after 7-day (p<0.05)twice-daily administration,respectively. |
推荐实验方法(仅供参考)
动物实验: |
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Monkeys Five adult cynomolgus monkeys (age,5-8 years;weight,3-5kg;sex,5 males) are used.All examinations are performed with the monkeys sitting in a modified monkey chair.On the first experimental day,after general anesthesia is induced by Ketamine hydrochloride at a dose of 8 to 10mg/kg intramuscularly,pupil dilation is induced with one drop of Tropicamide in both eyes.The NBONH,IOP,blood pressure,pulse rate,SaO2,and body temperature are measured at 9AM.Starting on the 2nd experimental day,Iganidipine (0.03% or 0.1%,30mL) is administered in one randomly chosen eye and vehicle solution into the other eye twice daily at 8AM and 8PM for 7 days.At 9AM on the 8th experimental day,the same measurements are repeated after general anesthesia and bilateral pupil dilation.After a 4-week interval,a second series of experiments is performed using a different Iganidipine concentration according to the same time schedule. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )