| 中文名称: | iFSP1 促销 | ||||
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| 英文名称: | iFSP1 | ||||
| CAS No: | 150651-39-1 | 分子式: | C20H13N5 | 分子量: | 323.35 |
| CAS No: | 150651-39-1 | ||||
| 分子式: | C20H13N5 | ||||
| 分子量: | 323.35 | ||||
基本信息
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产品编号：I10275 |
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产品名称：iFSP1 |
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CAS: |
150651-39-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
323.35 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
65mg/mL (201.02mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.0926mL |
15.4631mL |
30.9262mL |
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5mM |
0.6185mL |
3.0926mL |
6.1852mL |
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10mM |
0.3093mL |
1.5463mL |
3.0926mL |
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50mM |
0.0619mL |
0.3093mL |
0.6185mL |
生物活性
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产品描述 |
一种FSP1 (AIFM2) 的选择性有效抑制剂，EC50 值为 103 nM。 |
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靶点/IC50 |
FSP1/AIFM2 |
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103nM(EC50) |
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体外研究 |
iFSP1 (0.001-1μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.iFSP1 (0.001-1μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.iFSP1 (3μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1). Cell Proliferation Assay |
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Cell Line: |
Wild-type and Gpx4-knockout Pfa1 or HT 1080 cells overexpressing FSP1–HA |
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Concentration: |
0.001-1μM |
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Incubation Time: |
24 hours |
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Result: |
Was toxic to cells that depend solely (no GPX4 expression detectable) on FSP1 function. |
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Cell Viability Assay |
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Cell Line: |
NCl-H1437, NCl-H1437 FSP1 KO, U-373, U-373 FSP1 KO, MDA-MB-436, MDA-MB-436 FSP1 KO, SW620, SW620 FSP1 KO,MDA-MB-435S,MDA-MB-435S FSP1 KO, A549 and A549 FSP1 KO |
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Concentration: |
3μM |
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Incubation Time: |
24 hours |
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Result: |
Sensitized a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
