中文名称: | Icilin | ||||
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英文名称: | Icilin | ||||
别名: | Icilin AG3-5;3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone | ||||
CAS No: | 36945-98-9 | 分子式: | C16H13N3O4 | 分子量: | 311.3 |
CAS No: | 36945-98-9 | ||||
分子式: | C16H13N3O4 | ||||
分子量: | 311.3 |
基本信息
产品编号: |
I10167 |
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产品名称: |
Icilin |
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CAS: |
36945-98-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
311.30 |
-20℃ |
1个月 |
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化学名: |
3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.2124mL |
16.0622mL |
32.1244mL |
5mM |
0.6425mL |
3.2124mL |
6.4249mL |
10mM |
0.3212mL |
1.6062mL |
3.2124mL |
生物活性
产品描述 |
一种TRPM8离子通道激动剂。 |
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靶点 |
TRPM8 |
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体外研究 |
Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+ dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization. Cell Viability Assay |
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Cell Line: |
TRPM8-expressing oocytes or HEK293 cells |
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Concentration: |
10μM |
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Incubation Time: |
3 minutes for TRPM8-expressing oocytes;1 minute for HEK293 cells |
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Result: |
Activated membrane currents with variable delay of onset in voltage-clamped TRPM8- expressing oocytes or HEK293 cells. |
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体内研究 |
Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice.Icilin (3mg/kg;s.c.) induces“Wet dog shake”in mice. |
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Animal Model: |
The C57BL/6 mice 9–10 weeks (adult,26-30g) or 24 months (aged,35-42g). |
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Dosage: |
3mg/kg |
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Administration: |
Injected s.c. |
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Result: |
Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”),which were TRPM8-dependent. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )