| 中文名称: | HC-067047 促销 | ||||
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| 英文名称: | HC-067047 | ||||
| 别名: | HC-067047 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide | ||||
| CAS No: | 883031-03-6 | 分子式: | C26H28F3N3O2 | 分子量: | 471.51 |
| CAS No: | 883031-03-6 | ||||
| 分子式: | C26H28F3N3O2 | ||||
| 分子量: | 471.51 | ||||
基本信息
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产品编号： |
H10491 |
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产品名称： |
HC-067047 |
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CAS: |
883031-03-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
471.51 |
-20℃ |
1个月 |
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化学名： |
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide |
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Solubility (25°C)： |
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体外:
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DMSO |
94mg/mL (199.35mM) |
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Ethanol |
5mg/mL (10.6mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1208mL |
10.6042mL |
21.2085mL |
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5mM |
0.4242mL |
2.1208mL |
4.2417mL |
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10mM |
0.2121mL |
1.0604mL |
2.1208mL |
生物活性
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产品描述 |
一种有效的选择性TRPV4拮抗剂，可逆地抑制流经人，大鼠和小鼠TRPV4直系同源物的电流，IC50值分别为48nM，133nM和17nM。 |
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靶点 |
IC50:48nM (human TRPV4),133nM (rat TRPV4),17nM (mouse TRPV4) |
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体外研究 |
HC-067047 (1µM;24 hours;HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEIOC1 cells.HC-067047 (1µM;24 hours;HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein.HC-067047 (1µM;48 hours;HEI-OC1 cells) treatment inhibits cell proliferation.HC-067047 (1µM;48 hours;HEI-OC1 cells) treatment promotes cell apoptosis. RT-PCR |
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Cell Line: |
HEI-OC1 cells |
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Concentration: |
1µM |
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Incubation Time: |
24 hours |
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Result: |
The mRNA expression was significantly decreased. |
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Western Blot Analysis |
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Cell Line: |
HEI-OC1 cells |
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Concentration: |
1µM |
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Incubation Time: |
24 hours |
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Result: |
The expression of TRPV4 protein was significantly decreased. |
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Cell Proliferation Assay |
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Cell Line: |
HEI-OC1 cells |
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Concentration: |
1µM |
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Incubation Time: |
48 hours |
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Result: |
Inhibited cell proliferation. |
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Apoptosis Analysis |
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Cell Line: |
HEI-OC1 cells |
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Concentration: |
1µM |
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Incubation Time: |
48 hours |
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Result: |
Promoted cell apoptosis. |
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体内研究 |
HC-067047 (0-50mg/kg;intraperitoneal injection;for 30 minutes;cyclophosphamide-treated WT and Trpv4−/−mice,and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis.HC-067047 do not affect bladder function in Trpv4−/−mice. |
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Animal Model: |
Cyclophosphamide-treated WT and Trpv4−/−mice,and naive WT mice |
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Dosage: |
0mg/kg,1mg/kg,10mg/kg,50mg/kg |
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Administration: |
Intraperitoneal injection;for 30 minutes |
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Result: |
Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4−/−mice. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
