| 中文名称: | HJB97 | ||||
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| 英文名称: | HJB97 | ||||
| 别名: | HJB97;A16872;4-[(5-Cyclopropyl-2-ethylpyrazol-3-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-N-methyl-9H- | ||||
| CAS No: | 2093391-24-1 | 分子式: | C26H28N8O3 | 分子量: | 500.55 |
| CAS No: | 2093391-24-1 | ||||
| 分子式: | C26H28N8O3 | ||||
| 分子量: | 500.55 | ||||
基本信息
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产品编号：H10363 |
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产品名称：HJB97 |
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CAS: |
2093391-24-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量： |
938.04 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.9978mL |
9.9890mL |
19.9780mL |
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5mM |
0.3996mL |
1.9978mL |
3.9956mL |
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10mM |
0.1998mL |
0.9989mL |
1.9978mL |
生物活性
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产品描述 |
一种 BET bromodomains (BrD) 抑制剂，对于 BRD4-BD1/BD2 的 Ki 值为 18.4 nM。MS645 在空间上限制 BRD4 BrDs 的二价抑制，从而导致实体肿瘤细胞中 BRD4 转录活性的持续抑制。 |
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靶点/IC50 |
BRD4 BD1 0.5±0.2nM (Ki) |
BRD4 BD1 7.0±0.6nM (IC50) |
BRD4 BD2 1.0±0.1nM (Ki) |
BRD4 BD2 7.0±0.1nM (IC50) |
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BRD2 BD1 0.9±0.2nM (Ki) |
BRD2 BD2 0.27±0.09nM (Ki) |
BRD2 BD1 3.1±0.7nM (IC50) |
BRD2 BD2 3.9±0.5nM (IC50) |
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BRD3 BD1 0.18±0.01nM (Ki) |
BRD3 BD2 0.21±0.03nM (Ki) |
BRD3 BD1 6.6±0.2nM (IC50) |
BRD3 BD2 1.9±0.4nM (IC50) |
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体外研究 |
HJB97 is a highly potent and efficacious bomodomain and extra terminal (BET) inhibitor with IC50s of 3.1nM (BRD2 BD1),3.9nM (BRD2 BD2),6.6nM (BRD3 BD1),1.9nM (BRD3 BD2),7.0nM (BRD4 BD1),7.0nM (BRD4 BD2).HJB97 (10-1000nM,4 days) potently inhibits cell growth in RS4;11 and MOLM-13 acute leukemia cell lines with IC50s of 24.1nM and 25.6nM.HJB97 can effectively down-regulate the level of c-Myc at concentrations of 300-1000 nM in the RS4;11 cell line (treated for 24h). Cell Viability Assay |
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Cell Line: |
The human acute leukemia RS4;11 cell line;The human acute leukemia MOLM-13 cell line |
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Concentration: |
10-1000nM |
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Incubation Time: |
4 days |
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Result: |
Achieved IC50s value of 24.1±5.3nM and 25.6±1.9nM in inhibition of the RS4;11 cell and MOLM-13 cell growth. |
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Western Blot Analysis |
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Cell Line: |
RS4;11 cells |
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Concentration: |
30,100,300,1000nM |
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Incubation Time: |
24h |
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Result: |
Down-regulated the level of c-Myc but at concentrations of 300-1000nM in the RS4;11 cell line. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
