中文名称: | 羟基伊曲康唑 | ||||
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英文名称: | Hydroxy Itraconazole | ||||
别名: | 羟基伊曲康唑 Itraconazole metabolite Hydroxy Itraconazole; R-63373 | ||||
CAS No: | 112559-91-8 | 分子式: | C35H38Cl2N8O5 | 分子量: | 721.63 |
CAS No: | 112559-91-8 | ||||
分子式: | C35H38Cl2N8O5 | ||||
分子量: | 721.63 |
基本信息
产品编号:H10276 |
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产品名称:Hydroxy Itraconazole |
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CAS: |
112559-91-8 |
储存条件 |
粉末 |
2-8℃(避光) |
四年 |
分子式: |
溶于液体 |
-80℃(避光) |
六个月 |
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分子量 |
721.63 |
-20℃(避光) |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
100mg/mL (138.58mM Need ultrasonic) |
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Ethanol |
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Water |
< 0.1mg/mL |
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体内 |
现配现用 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.3858mL |
6.9288mL |
13.8575mL |
5mM |
0.2772mL |
1.3858mL |
2.7715mL |
10mM |
0.1386mL |
0.6929mL |
1.3858mL |
生物活性
产品描述 |
一种三唑类抗真菌剂 |
靶点/IC50 |
Antifungal |
体外研究 |
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ).Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration. |
体内研究 |
The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )