| 中文名称: | HMN-176 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | HMN-176 | ||||
| 别名: | (E)-4-(2-(4-methoxyphenylsulfonamido)styryl)pyridine 1-oxide (E)-4-(2-(4-methoxyphenylsulfonamido)styryl)pyridine 1-oxide | ||||
| CAS No: | 173529-10-7 | 分子式: | C20H18N2O4S | 分子量: | 382.43 |
| CAS No: | 173529-10-7 | ||||
| 分子式: | C20H18N2O4S | ||||
| 分子量: | 382.43 | ||||
一种合成抗肿瘤化合物HMN-214（H10028)的活性代谢物.
HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
