| 中文名称: | Guanabenz HCl | ||||
|---|---|---|---|---|---|
| 英文名称: | Guanabenz HCl | ||||
| 别名: | 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine;hydrochloride | ||||
| CAS No: | 23113-43-1 | 分子式: | C8H9Cl3N4 | 分子量: | 267.54 |
| CAS No: | 23113-43-1 | ||||
| 分子式: | C8H9Cl3N4 | ||||
| 分子量: | 267.54 | ||||
包装规格：
5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：
Guanabenz hydrochloride 是一种 α-2 肾上腺素受体激动剂，具有口服活性。Guanabenz hydrochloride 具有抗高血压和抗寄生虫活性。Guanabenz hydrochloride 干扰内质网应激信号传导，对心肌细胞具有保护作用。Guanabenz hydrochloride 也被用于高血压的研究。
储备液保存：
-80°C, 6 months
-20°C, 1 month
(sealed storage, away from moisture and light)
-20°C, 1 month
(sealed storage, away from moisture and light)
靶点：
Toxoplasma
体外研究：
Guanabenz hydrochloride(0.5-50μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability.
Guanabenz hydrochloride(0.5-50μM, 24 h) alone not affects the UPR targets,neither on mRNA or protein level nor the phosphorylation status of eIF2a.Guanabenz also not induces GADD34 or the constitutively active form CReP.
Guanabenz hydrochloride(0.5-50μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes.
Guanabenz hydrochloride(0.5-50μM, 24 h) alone not affects the UPR targets,neither on mRNA or protein level nor the phosphorylation status of eIF2a.Guanabenz also not induces GADD34 or the constitutively active form CReP.
Guanabenz hydrochloride(0.5-50μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes.
体内研究：
Guanabenz hydrochloride (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden.
Guanabenz hydrochloride (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice.
Guanabenz hydrochloride (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats.
Guanabenz hydrochloride (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice.
Guanabenz hydrochloride (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats.
保存条件：
2-8°C 密封干燥 避光
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
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安全说明：
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参考文献 & 客户发表文献
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质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
