010-60605840
结构式搜索
  1. 首页
  2. 产品目录
  3. Signaling Pathways(信号通路)
  4. GPCR/G Protein
  5. Adrenergic Receptor(肾上腺素能受体)
中文名称: Guanoxabenz hydrochloride
英文名称: Guanoxabenz hydrochloride
CAS No: 23256-40-8
分子式: C8H9Cl3N4O
分子量: 283.54
点击下载产品说明书(PDF)
G10739 Guanoxabenz hydrochloride ≥98% (psaitong)
包装规格：
5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：
溶于DMSO(80mg/mL超声）
产品描述：

基本信息

产品编号：

G10739

产品名称：

Guanoxabenz hydrochloride

CAS:

23256-40-8

 

储存条件

粉末

-20℃

四年

 

 

分子式：

C8H9Cl3N4O

溶于液体

-80℃

6个月

分子量：

283.54

-20℃

1个月

化学名： 

3-((2,6-Dichlorophenyl)methylene)-N-hydroxycarbazamidine hydrochloride

Solubility (25°C)：

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

＜1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

3.5268mL

17.6342mL

35.2684mL

5mM

0.7054mL

3.5268mL

7.0537mL

10mM

0.3527mL

1.7634mL

3.5268mL

 

生物活性

产品描述

一种α2 肾上腺素能 (α2 adrenergic receptor) 受体激动剂。

靶点

Adrenergic Receptor

 

体外研究

The formation of high-affinity Guanoxabenz binding seems to be inhibited by a series of N-hydroxyguanidine analogs to Guanoxabenz,as well as by a series of metabolic inhibitors that included allopurinol,Guanoxabenz and guanabenz are both known as centrally active antihypertensive drugs.High affinity Guanoxabenz binding is induced in rat brain membranes after addition of NADH or NADPH cofactors.The rat cerebral cortex contains an enzymatic activity that may activate Guanoxabenz leading to formation of a metabolite showing high affinity for alpha 2-adrenoceptors.Guanoxabenz (0.1-3mg/kg,i.p.) causes a dose-related reduction in locomotor activity;a dose of 1mg/kg is selected since this induces a pronounced and sustained behavioural hypoactivity.1-chloro-2,4-dinitrobenzene,5,59-dithiobis-(2-nitrobenzoic acid),cibacron blue,phenyl-p-benzoquinone,didox,and trimidox.The formation of Guanoxabenz high-affinity binding is also inhibited in a time-and concentration-dependent fashion by preincubating the membranes with the LW03 N-hydroxyguanidine analogue of Guanoxabenz.The spleen cytosolic fraction mediates the reduction of Guanoxabenz to guanabenz,the latter having an almost 100-fold higher affinity for rat alpha2A-adrenoceptors than Guanoxabenz itself.

体内研究

Guanoxabenz and guanabenz are both known as centrally active antihypertensive drugs. High affinity Guanoxabenz binding is induced in rat brain membranes after addition of NADH or NADPH cofactors.The rat cerebral cortex contains an enzymatic activity that may activate Guanoxabenz leading to formation of a metabolite showing high affinity for alpha 2-adrenoceptors.Guanoxabenz (0.1-3mg/kg,i.p.) causes a dose-related reduction in locomotor activity;a dose of 1 mg/kg is selected since this induces a pronounced and sustained behavioural hypoactivity.

Animal Model:

Rats.

Dosage:

0.5mg/kg (RX 781094 or saline vehicle was injected intravenously (tail vein) at the time of peak effect of the agonist (20min for clonidine and 30 min for Guanoxabenz).

Administration:

IP.

Result:

RX 781094 (0.1-1.0mg/kg,i.v.) produces a rapid (
保存条件：
-20℃
UN码：
HazardClass：
危害声明：
安全说明：
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
购物指南
参考资料
支付方式
关于配送
售后服务
微信二维码
首页 |网站使用条款 |隐私政策 |关于我们 |营业执照 |结构式搜索
© 2001-2020 北京普西唐生物科技有限公司  天津普西唐生物医药科技有限公司
版权所有，并保留所有权利 
备案号：京ICP备17064988号-1