| 中文名称: | Gliclazide | ||||
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| 英文名称: | Gliclazide | ||||
| 别名: | 格列齐特;N-((六氢环戊并[c]吡咯-2(1H)-基)氨甲酰)-4-甲基苯磺酰胺 S1702;SE1702 | ||||
| CAS No: | 21187-98-4 | 分子式: | C15H21N3O3S | 分子量: | 323.41 |
| CAS No: | 21187-98-4 | ||||
| 分子式: | C15H21N3O3S | ||||
| 分子量: | 323.41 | ||||
| EINEC: | 244-260-5 | ||||
| EINEC: | 244-260-5 | ||||
基本信息
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产品编号： |
G10584 |
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产品名称： |
Gliclazide |
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CAS: |
21187-98-4 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
323.41 |
-20℃ |
1个月 |
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化学名： |
1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea |
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Solubility (25°C)： |
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体外:
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DMSO |
65mg/mL (200.98mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.0921mL |
15.4603mL |
30.9205mL |
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5mM |
0.6184mL |
3.0921mL |
6.1841mL |
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10mM |
0.3092mL |
1.5460mL |
3.0921mL |
生物活性
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产品描述 |
全细胞的β细胞ATP敏感型钾流(potassiumcurrents)阻断剂，IC50为184nM，用作降糖药。 |
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靶点 |
Potassium Channel |
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体外研究 |
Gliclazide (S1702) further characterize its mechanism of hypoglycemic effect:the observed improvements in insulin sensitivity and in GLUT4 translocation indicate that gliclazide counters the hydrogen peroxide-induced insulin resistance in 3T3L1 adipocytes and also would further augment the hypoglycemic effect of this drug as insulinotropic sulfonylurea.Gliclazide blocked whole-cell beta-cell KATP currents with an IC50 of 184+/-30 nmol/l (n=6-10) but was much less effective in cardiac and smooth muscle (IC50s of 19.5+/-5.4 micromol/l (n=6-12) and 37.9+/-1.0 micromol/l (n=5-10),respectively).In all three tissues,the action of the drug on whole-cell KATP currents was rapidly reversible.In inside-out patches on beta-cells,gliclazide (1 micromol/l) produced a maximum of 66+/-13 % inhibition (n=5),compared with more than 98% block in the whole-cell configuration.Gliclazide is a high-potency sulphonylurea which shows specificity for the pancreatic beta-cell KATP channel over heart and smooth muscle.In this respect,it differs from glibenclamide. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
