| 中文名称: | GNE-0723 | ||||
|---|---|---|---|---|---|
| 英文名称: | GNE-0723 | ||||
| 别名: | GNE-0723 GNE-0723 | ||||
| CAS No: | 1883518-31-7 | 分子式: | C16H8ClF6N5Os | 分子量: | 467.78 |
| CAS No: | 1883518-31-7 | ||||
| 分子式: | C16H8ClF6N5Os | ||||
| 分子量: | 467.78 | ||||
一种可透过血脑屏障的NMDAR的正向调节剂
GNE-0723 is a highly potent and brain penetrant GluN2A-selective NMDAR PAM suitable for in vivo characterization. EC50 (GluN2A) = 0.021 microM; EC50 (GluNA2 Flip) = 9.1 microM; EC50 (GluNA2 Flop) = 5.5 microM. The N-methyl-D-aspartate receptor (NMDAR) is a Na+ and Ca2+ permeable ionotropic glutamate receptor that is activated by the coagonists glycine and glutamate. NMDARs are critical to synaptic signaling and plasticity, and their dysfunction has been implicated in a number of neurologicaldisorders, including schizophrenia, depression, and Alzheimer’s disease.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
