GSK-J4 hydrochloride - CAS:1797983-09-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	GSK-J4 hydrochloride
英文名称:	GSK-J4 hydrochloride
CAS No:	1797983-09-5	分子式:	C₂₄H₂₈ClN₅O₂	分子量:	453.96
CAS No:	1797983-09-5
分子式:	C₂₄H₂₈ClN₅O₂
分子量:	453.96

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G10426 GSK-J4 hydrochloride ≥98% (psaitong)

相关产品

包装规格：

100mg in glass bottle

溶解性：

溶于DMSO（62.5mg/mL 超声）

产品描述：

基本信息

产品编号：G10426
产品名称：GSK-J4 hydrochloride
CAS:	1797983-09-5	储存条件	粉末	-20℃	四年

分子式：	C24H28ClN5O2		溶于液体	-80℃	六个月
分子量：	453.96			-20℃	一个月
化学名：
Solubility (25°C)	体外	DMSO	90mg/mL warmed with 50ºC water bath (198.25mM)
		Ethanol	90mg/mL warmed with 50ºC water bath (198.25mM)
		Water	10mg/mL (22.02mM)
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.2028mL	11.0142mL	22.0284mL
5mM	0.4406mL	2.2028mL	4.4057mL
10mM	0.2203mL	1.1014mL	2.2028mL
50mM	0.0441mL	0.2203mL	0.4406mL

生物活性

产品描述	一种有效的 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂，IC50 分别为 8.6μM 和 6.6μM。GSK-J4 hydrochloride 抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α，IC50 值为 9μM。GSK-J4 hydrochloride 是 GSK-J1 的细胞通透性前药。
靶点/IC50	JMJD3 (Cell-free assay)
	60nM
体外研究	GSK-J4 Hydrochloride has cellular activity in Flag-JMJD3-transfected HeLa cells,in which GSK-J4 prevents the JMJD3-induced loss of nuclear H3K27me3 immunostaining.Administration of GSK-J4 increases total nuclear H3K27me3 levels in untransfected cells.GSK-J4 significantly reduces the expression of 16 of 34 LPS-driven cytokines,including tumour-necrosis factor-α(TNF-α).GSK-J4 Hydrochloride (5μM;48 hours) causes a more than 3-fold increase in mouse podocyte H3K27me3 content.H3K27me3 levels in cultured podocytes,GSK-J4 reduces Jagged-1 mRNA and Jagged-1 protein levels.Correspondingly,when exposed podocytes to the inducer of dedifferentiation TGF-β1,pretreatment with GSK-J4 preventes both the increase in intracellular N1-ICD levels and the increase in α-SMA and the decrease in podocin mRNA levels.GSK-J4 Hydrochloride (10,25nM) acts upon DCs promoting the differentiation of Treg cells,improving Treg stability and suppressive capacities,without affecting the differentiation of Th1 and Th17 cells.GSK-J4 Hydrochloride inhibits JMJD3 expression that is induced by TGF-β1.GSK-J4 Hydrochloride inhibits H3K4 demethylation at Xist,Nodal,and HoxC13 in female embryonic stem cells.
体内研究	GSK-J4 Hydrochloride (10mg/kg;i.p.; thrice-weekly for 10 weeks) attenuates the development of kidney disease in diabetic mice.GSK-J4 Hydrochloride (0.5mg/kg,i.p.) significantly reduces the severity and delays the onset of the disease of the mouse model of experimental autoimmune encephalomyelitis.
	Animal Model:	Eight-week-old male db/m and db/db mice on a BKS background
	Dosage:	10mg/kg
	Administration:	i.p.;thrice-weekly for 10 weeks
	Result:	Attenuated the development of kidney disease in diabetic mice.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果