中文名称: | Galidesivir hydrochloride | ||||
---|---|---|---|---|---|
英文名称: | Galidesivir hydrochloride | ||||
别名: | (2S,3S,4R,5R)-2-(4-氨基-5H-吡咯并[3,2-D]嘧啶-7-基)-5-(羟基甲基)-3,4-吡咯烷二醇单盐酸盐;(2S,3S,4R,5R)-2-(4-氨基-5H-吡咯并[3,2-d]嘧啶-7-基)-5-(羟基甲基)-3,4-吡咯烷二醇单盐酸盐 BCX 4430 hydrochloride; Immucillin-A hydrochloride | ||||
CAS No: | 222631-44-9 | 分子式: | C11H16ClN5O3 | 分子量: | 301.73 |
CAS No: | 222631-44-9 | ||||
分子式: | C11H16ClN5O3 | ||||
分子量: | 301.73 |
基本信息
产品编号:G10331 |
|||||
产品名称:Galidesivir hydrochloride |
|||||
CAS: |
222631-44-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
六个月 |
||
分子量 |
301.73 |
-20℃ |
一个月 |
||
化学名: |
|||||
Solubility (25°C) |
体外 |
DMSO |
|
||
Ethanol |
|
||||
Water |
|
||||
体内 |
现配现用 |
|
|||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.3142mL |
16.5711mL |
33.1422mL |
5mM |
0.6628mL |
3.3142mL |
6.6284mL |
10mM |
0.3314mL |
1.6571mL |
3.3142mL |
生物活性
产品描述 |
一种腺苷类似物和直接作用的抗病毒药物,能破坏病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 活性。 |
|
靶点/IC50 |
RdRp inhibitor |
|
体外研究 |
Cellular kinases phosphorylate Galidesivir (BCX4430) hydrochloride to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination. Galidesivir hydrochloride effectively inhibits the infection of Vero cells with YFV. The EC50 determined by the neutral red uptake assay is 8.3μg/ml (24.5μM). |
|
体内研究 |
Galidesivir (BCX4430) hydrochloride is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir hydrochloride has demonstrated pronounced efficacy. Galidesivir hydrochloride (4mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF) |
|
Animal Model: |
Female Syrian golden hamsters (hamsters infected with YF virus) |
|
Dosage: |
4mg/kg of body weight |
|
Administration: |
I.p.; twice daily for 7 days |
|
Result: |
Significantly improved the survival of hamsters infected with YFV. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )