| 中文名称: | FPTQ | ||||
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| 英文名称: | FPTQ | ||||
| 别名: | FPTQ 6-[1-(2-Fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline | ||||
| CAS No: | 864863-72-9 | 分子式: | C17H12FN5 | 分子量: | 305.31 |
| CAS No: | 864863-72-9 | ||||
| 分子式: | C17H12FN5 | ||||
| 分子量: | 305.31 | ||||
基本信息
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产品编号： |
F10708 |
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产品名称： |
FPTQ |
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CAS: |
864863-72-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
305.31 |
-20℃ |
1个月 |
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化学名： |
6-[1-(2-Fluoropyridin-3-yl)-5-methyltriazol-4-yl]quinoline |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.2754mL |
16.3768mL |
32.7536mL |
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5mM |
0.6551mL |
3.2754mL |
6.5507mL |
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10mM |
0.3275mL |
1.6377mL |
3.2754mL |
生物活性
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产品描述 |
一种有效的 mGluR1 拮抗剂，抑制人和鼠的 IC50 值分别为 6nM 和 1.4nM。FPTQ 具有抗氧化、抗炎作用。 |
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靶点 |
Human mGluR1 6nM (IC50) |
Mouse mGluR1 1.4nM (IC50) |
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体外研究 |
FPTQ (0.5-10μM) does not shows any cytotoxicity was not observed at 0.5,1,5,and 10μM in RAW264.7 macrophage cells.FPTQ (1-20μM;24 hours) reduces LPS-induced NO production at>1μM FPTQ, and at 10μM,FPTQ treatment causes a 31% anti-oxidant effect in RAW264.7 macrophage cells.FPTQ (1-20μM;24 hours) dramaticly decreases LPS-induced expression levels of IL-1β and Il-6. At a concentration of 10μM,FPTQ causes a 27% and 44% reduction in the mRNA expression of IL-1β and Il-6,respectively in RAW264.7 macrophage cells. RT-PCR |
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Cell Line: |
RAW264.7 macrophage cells |
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Concentration: |
1,10,or 20μM |
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Incubation Time: |
24 hours |
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Result: |
Decreased IL-1β and IL-6 mRNA expression |
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体内研究 |
FPTQ (5-20μM) decreases the number of neutrophils migrating to the amputation site in zebrafish larvae by tail amputation.In the tailfin wound method,the number of neutrophils collecting at the wound site also decreases in a dose-dependent manner in zebrafish.In a LPS-induced inflammation zebrafish model,LPS solution is injected into the yolks of Tg(mpx:EGFP)i114 zebrafish larvae and exposed the zebrafish larvae immediately to FPTQ treatment.FPTQ (20μM;4 hours) significantly decreases the fluorescent neutrophils after yolk injection and has an anti-inflammatory effect during the early phase of inflammation. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
