| 中文名称: | 氟马西尼 促销 | ||||
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| 英文名称: | Flumazenil | ||||
| 别名: | 8-氟-5-甲基-6-氧代-5,6-二氢-4H-苯并[F]咪唑[1,5-a][1,4]二氮杂卓-3-羧酸乙酯 Ro15-1788 | ||||
| CAS No: | 78755-81-4 | 分子式: | C15H14FN3O3 | 分子量: | 303.29 |
| CAS No: | 78755-81-4 | ||||
| 分子式: | C15H14FN3O3 | ||||
| 分子量: | 303.29 | ||||
| MDL: | MFCD00242764 | ||||
基本信息
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产品编号： |
F10428 |
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产品名称： |
Flumazenil |
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CAS: |
78755-81-4 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
303.29 |
-20℃ |
1个月 |
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化学名： |
Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate |
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Solubility (25°C)： |
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体外:
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DMSO |
7mg/mL (23.08mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.2972mL |
16.4859mL |
32.9717mL |
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5mM |
0.6594mL |
3.2972mL |
6.5943mL |
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10mM |
0.3297mL |
1.6486mL |
3.2972mL |
生物活性
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产品描述 |
一种有竞争性的GABAAreceptor拮抗剂，有潜力用于苯二氮类药物过量问题。 |
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靶点 |
GABA Receptor |
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体内研究 |
Flumazenil interacts at the central benzodiazepine receptor to antagonize or reverse the behavioral,neurologic,and electrophysiologic effects of benzodiazepine agonists and inverse agonists.Flumazenil is of some benefit in hepatic encephalopathy,but until well-designed clinical trials are conducted,hepatic encephalopathy must be considered an investigational indication for flumazenil.Flumazenil has been shown to reverse sedation caused by intoxication with benzodiazepines alone or benzodiazepines in combination with other agents, but it should not be used when cyclic antidepressant intoxication is suspected.Flumazenil (1mg/kg) induces a strong anxiolytic effect in BALB/c mice tested in the elevated plus maze and light/dark test.Flumazenil (10mg/kg) effectively prevents the reduction produced by allopregnanolone in rats.Flumazenil (5-20mg/kg) antagonizes the anticonvulsant and adverse effects of diazepam but not GYKI 52466 in mice.Flumazenil slightly reduces the anticonvulsant activity of NBQX in the MES model but not in the PTZ test.Flumazenil (3.0mg/kg) blocks the changes withdrawal from chronic ethanol treatment,which leads to a decrease in open arm time and percent open arm entries. |
推荐实验方法(仅供参考)
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动物实验: |
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Flumazenil is administered intraperitoneally in a volume of 10mL/kg body weight 20 min before experimental testing.Two polyvinylchloride boxes (20×20×14cm) covered with Plexiglas are connected by an opaque plastic tunnel (5×7×10cm).One of these boxes is darkened.A light from a 100-W desk lamp 40cm above the other box provided the only room illumination.This light level (300 lux) is chosen in order to avoid strain differences to be detected on time in the lit box (a measure of anxiety behaviour) in control animals. Indeed,in previous experiments,the BALB/c mice differ from C57BL/6 only in the high light condition.The subjects are individually tested in 5-min sessions between 1400 and 1700 hours.Mice are placed in the lit box to start the test session.The time spent in the lit box and the number of transitions from the dark box to the lit one are recorded after the first entry in the tunnel. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
