| 中文名称: | 法莫替丁 | ||||
|---|---|---|---|---|---|
| 英文名称: | Famotidine | ||||
| 别名: | 3-(((2-胍基噻唑-4-基)甲基)硫基)-N-氨基磺酰基丙脒 MK-208 | ||||
| CAS No: | 76824-35-6 | 分子式: | C8H15N7O2S3 | 分子量: | 337.45 |
| CAS No: | 76824-35-6 | ||||
| 分子式: | C8H15N7O2S3 | ||||
| 分子量: | 337.45 | ||||
| MDL: | MFCD00079297 | ||||
基本信息
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产品编号： |
F10409 |
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产品名称： |
Famotidine |
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CAS: |
76824-35-6 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
337.45 |
-20℃ |
1个月 |
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化学名： |
3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N-sulfamoylpropanimidamide |
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Solubility (25°C)： |
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体外:
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DMSO |
67mg/mL (198.54mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
2.9634mL |
14.8170mL |
29.6340mL |
|
5mM |
0.5927mL |
2.9634mL |
5.9268mL |
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10mM |
0.2963mL |
1.4817mL |
2.9634mL |
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50mM |
0.0593mL |
0.2963mL |
0.5927mL |
生物活性
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产品描述 |
一种组胺H2受体拮抗剂，可抑制胃液分泌。 |
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靶点 |
Histamine H2 Receptor. |
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体外研究 |
Famotidine (MK-208) is a histamine H2-receptor antagonist that inhibits stomach acid production,and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD).Famotidine (MK-208) Group(2mg/kg/day) were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery.Famotidine (MK-208) exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats.Famotidine (MK-208) increased the transgastric potential difference (PD) and promoted the recovery of decreased transgastric PD induced by acidified ethanol in rats. The preventive effect of famotidine on gastric lesions is attributable not only to suppression of acid secretion but to activation of the gastric mucosal defensive mechanisms. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
