中文名称: | FIIN-2 | ||||
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英文名称: | FIIN-2 | ||||
别名: | FIIN-2 N-(4-((3-(3,5-dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide | ||||
CAS No: | 1633044-56-0 | 分子式: | C35H38N8O4 | 分子量: | 634.73 |
CAS No: | 1633044-56-0 | ||||
分子式: | C35H38N8O4 | ||||
分子量: | 634.73 |
一种有效的、选择性的、不可逆的FGFR抑制剂,对FGFR1/2/3/4的IC50分别为3.09nM、4.3nM、27nM和45.3nM。
FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip。
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )