中文名称: | E4CPG | ||||
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英文名称: | E4CPG | ||||
别名: | 4-(1-Amino-1-carboxypropyl)benzoic acid | ||||
CAS No: | 170846-89-6 | 分子式: | C11H13NO4 | 分子量: | 223.23 |
CAS No: | 170846-89-6 | ||||
分子式: | C11H13NO4 | ||||
分子量: | 223.23 |
基本信息
产品编号: |
E10620 |
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产品名称: |
E4CPG |
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CAS: |
170846-89-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
223.23 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.4797mL |
22.3984mL |
44.7968mL |
5mM |
0.8959mL |
4.4797mL |
8.9594mL |
10mM |
0.4480mL |
2.2398mL |
4.4797mL |
生物活性
产品描述 |
一种 Group I/Group II 代谢型谷氨酸受体 (Group I/Group II metabotropic glutamate receptor) 的拮抗剂。E4CPG 可以抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。 |
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靶点 |
mGluR |
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体外研究 |
E4CPG acts at rat cortical mGluR with the KB value of 0.367mM. |
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体内研究 |
E4CPG (3-30nmol/site (i.t.),1-10μmol/paw (i.pl.),and 1-10nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.;30μmol/paw),and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.),49% (i.t.) and 40% (i.c.v.).E4CPG (35nM/3.5μL,i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG,100nM/5μL,i.c.v.) in male Sprague-Dawley rats. |
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Animal Model: |
Male Swiss mice (25-35g) |
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Dosage: |
3-30 nmol/site (i.t.),1-10μmol/paw (i.pl.) and 1-10nmol/ site (i.c.v.) |
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Administration: |
Single injection |
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Result: |
The maximal inhibition values for the antinociceptive action of E4CPG in glutamateinduced nociception were 48% (i.pl.),49% (i.t.) and 40% (i.c.v.). |
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Animal Model: |
Male Sprague-Dawley rats |
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Dosage: |
35nM/3.5μL |
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Administration: |
Single injection,i.c.v. |
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Result: |
Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG). |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )