中文名称: | Ertiprotafib | ||||
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英文名称: | Ertiprotafib | ||||
别名: | Ertiprotafib PTP112;(2R)-2-(4-(9-Bromo-2,3-dimethylnaphtho(2,3-b)thiophen-4-yl)-2,6-dimethylphenoxy)-3-phenylpropionic acid | ||||
CAS No: | 251303-04-5 | 分子式: | C31H27BrO3S | 分子量: | 559.51 |
CAS No: | 251303-04-5 | ||||
分子式: | C31H27BrO3S | ||||
分子量: | 559.51 |
一种PTP1B,IKK-β的抑制剂,其IC50值分别是1.6μM,400nM,同时也是PPARα/PPARβ的激动剂,其EC50值为~1μM。
Ertiprotafib, also known as PTP-112, is a Protein Tyrosine Phosphatase 1B Inhibitor (PTP1B inhibitor). Ertiprotafib normalized the plasma glucose and insulin levels in diabetic animal models, and progressed to a phase II clinical trial. Ertiprotafib is potentially useful for the treatment of Non-Insulin Dependent Diabetes. Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms. Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta), with an IC(50) of 400nM.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )