乙琥胺 - CAS:77-67-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	乙琥胺
英文名称:	Ethosuximide
别名:	乙琥胺;3-乙基-3-甲基吡咯烷-2,5-二酮 3-Ethyl-3-methylpyrrolidine-2,5-dione
CAS No:	77-67-8	分子式:	C₇H₁₁NO₂	分子量:	141.17
CAS No:	77-67-8
分子式:	C₇H₁₁NO₂
分子量:	141.17
EINEC:	201-048-7
EINEC:	201-048-7

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E10465 乙琥胺 ≥98% (psaitong)

相关产品

包装规格：

1g 5g in glass bottle

溶解性：

溶于DMSO(100mg/ml超声)

产品描述：

基本信息

产品编号：	E10465
产品名称：	Ethosuximide
CAS:	77-67-8	储存条件	粉末	2-8℃ 充氮保存	四年

分子式：	C7H11NO2		溶于液体	-80℃	6个月
分子量：	141.17			-20℃	1个月
化学名：	3-Ethyl-3-methylpyrrolidine-2,5-dione
Solubility (25°C)：
体外:	DMSO	28mg/mL (198.34mM)
	Ethanol	28mg/mL (198.34mM)
	Water	28mg/mL (198.34mM)
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	7.0837mL	35.4183mL	70.8366mL
5mM	1.4167mL	7.0837mL	14.1673mL
10mM	0.7084mL	3.5418mL	7.0837mL

生物活性

产品描述

一种广泛使用的抗癫痫药物，可改善多种神经退行性疾病模型的表型，且可阻断低电压激活的T型钙通道。

靶点

calcium channel

体外研究

The efficacy of Ethosuximide in generalized absence epilepsy is thought to be due to blockade of the low voltage activated T-type calcium channel.There is no reduction in total Tau levels in Ethosuximide treated Tau transgenic worms as compare to vehicle controls.The rescuing effect of Ethosuximide is therefore not due to transgene suppression or reduced expression of toxic mutant Tau protein.Quantification of the amount of soluble and insoluble (RIPA-extractable) Tau relative to total Tau levels reveals a significant reduction in aberrantly-folded,insoluble Tau and a corresponding increase in soluble Tau in Ethosuximide-treated compare with untreated worms.Concentrations of 2μM or more of Ethosuximide not only are found to be less effective than 1μM concentration of Ethosuximide,but also induce cell toxicity.GABA staining immunofluorescence images show that after treatment with Ethosuximide,GABA positive neuron increases by 3 and 6.5 fold for concentrations of 0.1 and 1μM,respectively.BrdU staining shows nuclei proliferation after 2 to 3 days of Ethosuximide exposure.The mean of nuclei is 15.98±0.41 for the low concentration of Ethosuximide while it is 25.27±0.48 for the high concentration after Brdu staining.This number is 11.05±0.2 for lithium chloride.

推荐实验方法(仅供参考)

激酶实验：

Vehicle-and Ethosuximide-treated Tau V337M worms are lysed and separated into soluble and insoluble fractions.Fractions are separated by SDS-PAGE and western blotted using anti-human Tau T46 and anti-actin antibodies.The abundance of Tau protein in each fraction is quantified by densitometry and normalized against beta-actin.Total Tau levels in lysates are expressed as the percentage of actin-normalized Tau relative to vehicle control lysates;Tau levels in sequentially extracted fractions are expressed as the percentage of actin-normalized Tau relative to the sum of both fractions (soluble+RIPA) combined.

细胞实验:

Neuronal stem cells from the forebrain Cortex of a 3-day-old rat are used in this study.The cells are differentiated by withdrawal of basic fibroblastic growth factor (bFGF) and exposed to Ethosuximide at two concentrations of 0.1μM and 1μM.Before drug treatment, the cells are rinsed once with PBS,and the medium is replaced with fresh,bFGF-free DMEM/F12 medium containing different concentration of Ethosuximide. Medium exchange is done every day for 6 days with medium containing Ethosuximide.Then,cells are fixed for immunocytochemistry.

保存条件：

2-8℃ 充氮保存

UN码：

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安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果