| 中文名称: | 5'-N-Ethylcarboxamidoadenosine | ||||
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| 英文名称: | 5'-N-Ethylcarboxamidoadenosine | ||||
| 别名: | 5'-N-乙基酰胺基腺苷 NECA | ||||
| CAS No: | 35920-39-9 | 分子式: | C12H16N6O4 | 分子量: | 308.29 |
| CAS No: | 35920-39-9 | ||||
| 分子式: | C12H16N6O4 | ||||
| 分子量: | 308.29 | ||||
| MDL: | MFCD00069195 | ||||
基本信息
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产品编号： |
E10412 |
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产品名称： |
5'-N-Ethylcarboxamidoadenosine |
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CAS: |
35920-39-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
308.29 |
-20℃ |
1个月 |
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化学名： |
(2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide |
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Solubility (25°C)： |
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体外:
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DMSO |
62mg/mL (201.1mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.2437mL |
16.2185mL |
32.4370mL |
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5mM |
0.6487mL |
3.2437mL |
6.4874mL |
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10mM |
0.3244mL |
1.6218mL |
3.2437mL |
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50mM |
0.0649mL |
0.3244mL |
0.6487mL |
生物活性
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产品描述 |
一个非选择性的腺苷受体激动剂。 |
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靶点 |
Adenosine receptor |
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体内研究 |
After the administration of 5'-N-Ethylcarboxamidoadenosine (NECA),the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5'-N-Ethylcarboxamidoadenosine (NECA):F(4,12)=14.9;P<0.001].The administration of 5'-N-Ethylcarboxamidoadenosine (NECA) [F(4,12)=16.1;P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment.Daily i.p.injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats,but does not affect control rats.Daily treatment with NECA (0.3mg/kg/day,i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats,but does not affect control rats.Daily i.p.injection of 5'-NEthylcarboxamidoadenosine (NECA) at 0.3mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats,but does not affect control rats. |
推荐实验方法(仅供参考)
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动物实验: |
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Male Wistar rats are used in this experiment.These animals range in weight between 350 and 425g.They are housed individually in hanging wire cages under a 12-h light/dark cycle.The effects of 5'-N-Ethylcarboxamidoadenosine (NECA) are tested in four rats.In the experiment,either 5'-N-Ethylcarboxamidoadenosine (NECA) (5,7.5,10,20μg/kg) or vehicle (saline) is administered intraperitoneally 15 min prior to the start of test sessions.5'-N-Ethylcarboxamidoadenosine (NECA) is administered following a random order crossover design.In most cases,animals are tested twice with the same dose. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
