中文名称: | E7820 | ||||
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英文名称: | E7820 | ||||
别名: | ER68203-00 | ||||
CAS No: | 289483-69-8 | 分子式: | C17H12N4O2S | 分子量: | 336.37 |
CAS No: | 289483-69-8 | ||||
分子式: | C17H12N4O2S | ||||
分子量: | 336.37 |
基本信息
产品编号:E10391 |
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产品名称:E7820 |
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CAS: |
289483-69-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
336.37 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
67mg/mL (199.18mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.9729mL |
14.8646mL |
29.7292mL |
5mM |
0.5946mL |
2.9729mL |
5.9458mL |
10mM |
0.2973mL |
1.4865mL |
2.9729mL |
50mM |
0.0595mL |
0.2973mL |
0.5946mL |
生物活性
产品描述 |
一种具有口服活性芳香族磺酰胺衍生物,是一种独特的血管生成 (angiogenesis) 抑制剂,可抑制内皮上整合素 α2 (integrin alpha2) 亚基的表达。E7820 抑制大鼠主动脉血管生成,IC50 为 0.11μg/ml。E7820 调节 α-1,α-2,α-3 和 α-5 整联素 mRNA 表达。具有抗血管生成和抗肿瘤活性。 |
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靶点/IC50 |
Integrin |
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体外研究 |
E7820 (ER68203-00) inhibits both bFGF- and VEGF-driven ube formation of human umbilical vascular endothelial cell (HUVEC) in a dose-dependent manner with IC50 of 0.20 and 0.24μg/ml,respectively.E7820 inhibits proliferation of HUVEC induced by either bFGF or VEGF in serum-free medium (SFM). The IC50 values are 0.10 and 0.081μg/ml, respectively. Antiproliferative activity of E7820 against both WiDr and LoVo cells is very weak compared with that against HUVEC. The values of IC50 were 29 and 15μg/ml,respectively. |
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体内研究 |
E7820 (ER68203-00) (50-200 mg/kg; p.o. ; twice daily for 14 days) delays the growth of WiDr cells inoculated s.c..E7820 (200-400mg/kg;p.o.;once daily for 4 days) potently inhibits WiDr-induced angiogenesis. |
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Animal Model: |
Six-week-old female nude mice (KSN mice, WiDr-induced angiogenesis model) |
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Dosage: |
50, 100, 200mg/kg |
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Administration: |
p.o.;twice daily for 14 days from 2 days after inoculation of the tumor cells |
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Result: |
The antitumor effect was dose-dependent at 50,100,and 200mg/kg,and the tumor growth rates were 52%,46%,and 27%,respectively. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )