大黄素 - CAS:518-82-1 - CAS号查询_生物试剂_化学试剂_分析试剂_实验试剂-普西唐试剂商城

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中文名称:	大黄素
英文名称:	Emodin
别名:	朱砂莲甲素 1'3'8-三羟基-6-甲基蒽醌 Emodin
CAS No:	518-82-1	分子式:	C₁₅H₁₀O₅	分子量:	270.24
CAS No:	518-82-1
分子式:	C₁₅H₁₀O₅
分子量:	270.24
MDL:	MFCD00001207	EINEC:	208-258-8
EINEC:	208-258-8

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E10028 大黄素 ≥95%(HPLC) (psaitong)

相关产品

包装规格：

1g 5g 25g in glass bottle

溶解性：

溶于10mg/mL氢氧化铵溶液。

产品描述：

基本信息

产品编号：	E10028
产品名称：	Emodin
CAS:	518-82-1	储存条件	粉末	2-8℃	四年

分子式：	C15H10O5		溶于液体	-80℃	两年
分子量	270.24			-20℃	一个月
化学名：	1,3,8-trihydroxy-6-methylanthracene-9,10-dione
Solubility (25°C)：
体外:	DMSO	54mg/mL (199.82mM)
	Ethanol	3mg/mL (11.1mM)
	Water	Insoluble
体内(现配现用):	1.请依序添加每种溶剂：0.5% MC→0.5% Tween-80 Solubility: 10mg/mL (37.00mM); Suspended solution; Need ultrasonic
	2.请依序添加每种溶剂：0.5% CMC-Na/saline water Solubility: 3.33mg/mL (12.32mM); Suspened solution; Need ultrasonic
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.7004mL	18.5021mL	37.0041mL
5mM	0.7401mL	3.7004mL	7.4008mL
10mM	0.3700mL	1.8502mL	3.7004mL
50mM	0.0740mL	0.3700mL	0.7401mL

生物活性

产品描述	抑制NF-κB活化和粘附分子表达。酪蛋白激酶2（CK2）抑制剂。
靶点	11β-HSD1
体外研究	Emodin (10-400μM) blocks the binding of S protein to ACE2 in a dose-dependent manner with the IC50 value of 200μM. Emodin (5-50μM) inhibits the S protein-pseudotyped retrovirus infectivity in a dose-dependent manner. Emodin blocks the SARS-CoV S protein binding to Vero E6 cells. Emodin inhibits casein kinase-2 (CK2) with IC50s of 5.9, 30.0, and 7.1μM for CK2α Wild-type, Ile174Ala mutant, and His160Ala mutant at ATP concentration is 50μM, respectively. The IC50s are 1.40 and 38.00μM for CK2α Wild-type, and Val66Ala mutant at ATP concentration is 10μM. Emodin exhibits low inhibitory activity against mouse and human 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), with an IC50 higher than 1mM, indicating that Emodin is more than 5000-fold selective for the human and mouse 11β-HSD1 enzymes over the type 2 isoenzyme Cell Viability Assay
	Cell Line:	Vero E6 cells transfected with the plasmid encoding ACE2
	Concentration:	0, 5, 25, 50μM
	Incubation Time:	24 hours
	Result:	Vero cells treated with 50μM remained 82.4±3.8% viability, the anti-SARS-CoV activity was not due to toxicity.
体内研究	Emodin (single oral administration of 100 or 200mg/kg) inhibits 11β-HSD1 activity in normal C57BL/6J male mice. Emodin (100mg/kg; oral administration; b.i.d.) improves insulin sensitivity and lipid metabolism, and lowers blood glucose and hepatic PEPCK, and glucose-6-phosphatase mRNA in diet-induced obese (DIO) mice
	Animal Model:	C57BL/6J male mice
	Dosage:	100 or 200mg/kg
	Administration:	Acute administered p.o. ; Two hours later, the mice were killed by cervical dislocation,
	Result:	Significantly inhibited liver 11β-HSD1 enzymatic activity by 17.6 and 31.3% and mesenteric fat 11β-HSD1 enzymatic activity by 21.5 and 46.7% at 100 or 200mg/kg, respectively.

	Animal Model:	DIO mice (C57BL/6J male mice were fed a formulated research diet)
	Dosage:	100mg/kg
	Administration:	Oral gavage; twice per day; for 35 days
	Result:	Reduced fasting glucose concentrations to 77.2% of the vehicle control mice after 7 days of treatment, and these remained significantly lower throughout the treatment period. Exhibited a significant reduction in blood glucose levels at all time-points following oral glucose challenge after 24 days of treatment. Evoked a significantly greater reduction in blood glucose values 40 and 90 min after insulin injection after 28 days of treatment. The serum insulin level was also significantly reduced, to 66.2% of control mice, after 35 days of treatment. Improved the lipid profiles. The serum triglyceride and total cholesterol levels were significantly reduced by 19.3 and 12.5% after 35 days of treatment, respectively. Caused a 22.7% reduction of non-esterified free fatty acid (NEFA) level. Lowered body weight and appetite from day 18 of the treatment; their body weights were reduced by 13.9% at the end of treatment.

保存条件：

2-8℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:		LOG(C1):
C2=C1/X	C2:		LOG(C2):
C3=C2/X	C3:		LOG(C3):
C4=C3/X	C4:		LOG(C4):
C5=C4/X	C5:		LOG(C5):
C6=C5/X	C6:		LOG(C6):
C7=C6/X	C7:		LOG(C7):
C8=C7/X	C8:		LOG(C8):

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